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LOC127885326 NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1302739-1303376 [ Homo sapiens (human) ]

Gene ID: 127885326, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127885326
Gene description
NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1302739-1303376
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive and primed human embryonic stem cells. This enhancer associates with the NANOG transcription factor and is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Dec 2022]
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Genomic context

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See LOC127885326 in Genome Data Viewer
Location:
chromosome: 17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (1399445..1400082)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (1288169..1288806)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (1302739..1303376)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:1174140-1174890 Neighboring gene basic helix-loop-helix family member a9 Neighboring gene trafficking regulator of GLUT4 (SLC2A4) 1 (gene/pseudogene) Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:1202102-1202696 Neighboring gene Sharpr-MPRA regulatory region 14526 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1295206-1295734 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1302101-1302738 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1303377-1304014 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:1304957-1305572 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:1305573-1306188 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:1335344-1335844 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:1335845-1336345 Neighboring gene Sharpr-MPRA regulatory region 4720 Neighboring gene CRK proto-oncogene, adaptor protein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:1357059-1357560 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1358695-1359680 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11449 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1366499-1367318 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:1371831-1372451 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7954 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11450 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11451 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11452 Neighboring gene myosin IC Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7955 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7956 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7957 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1394312-1395031

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_135067.1 

    Range
    101..738
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    1399445..1400082
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    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187613.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    341471..342108
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    1288169..1288806
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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