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LOC127829004 OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:25888031-25888974 [ Homo sapiens (human) ]

Gene ID: 127829004, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127829004
Gene description
OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:25888031-25888974
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in primed human embryonic stem cells. This enhancer associates with the OCT4 and NANOG transcription factors and is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Nov 2022]
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Genomic context

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See LOC127829004 in Genome Data Viewer
Location:
chromosome: 15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (25642884..25643827)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (23380704..23381647)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (25888031..25888974)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2250 Neighboring gene uncharacterized LOC107984789 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:25808594-25809158 Neighboring gene uncharacterized LOC124903448 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:25895885-25896385 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:25917854-25918562 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:25918563-25919270 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:25940327-25940827 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:25941814-25942360 Neighboring gene ATPase phospholipid transporting 10A (putative) Neighboring gene RNA, 5S ribosomal pseudogene 390 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:26014919-26015420 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9163 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:26047324-26047457 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:26047665-26048164 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:26056572-26057072 Neighboring gene uncharacterized LOC107984770

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_130490.1 

    Range
    101..1044
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    25642884..25643827
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    23380704..23381647
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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