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LOC127825237 H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:117319439-117320400 [ Homo sapiens (human) ]

Gene ID: 127825237, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127825237
Gene description
H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:117319439-117320400
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive human embryonic stem cells. This enhancer is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Nov 2022]
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Genomic context

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See LOC127825237 in Genome Data Viewer
Location:
chromosome: 12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (116881634..116882595)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (116862702..116863663)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (117319439..117320400)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ring finger protein, transmembrane 2 Neighboring gene RNA, U6 small nuclear 558, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7101 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4906 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:117276582-117276778 Neighboring gene Sharpr-MPRA regulatory region 3661 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:117311807-117312016 Neighboring gene MPRA-validated peak1984 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4907 Neighboring gene harakiri, BCL2 interacting protein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4908 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4909 Neighboring gene ribosomal protein L36 pseudogene 15 Neighboring gene F-box and WD repeat domain containing 8 Neighboring gene uncharacterized LOC100506551

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_126750.1 

    Range
    101..1062
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    116881634..116882595
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    116862702..116863663
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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