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LOC127818012 OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:53670167-53671089 [ Homo sapiens (human) ]

Gene ID: 127818012, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127818012
Gene description
OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:53670167-53671089
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive and primed human embryonic stem cells. This enhancer associates with the OCT4 and NANOG transcription factors and is marked by the H3K27ac histone modification. [provided by RefSeq, Nov 2022]
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Genomic context

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See LOC127818012 in Genome Data Viewer
Location:
chromosome: 10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (51910407..51911329)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (52759524..52760445)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (53670167..53671089)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene protein kinase cGMP-dependent 1 Neighboring gene Ras suppressor protein 1 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3374 Neighboring gene Sharpr-MPRA regulatory region 685 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:53469036-53469536 Neighboring gene cleavage stimulation factor subunit 2 tau variant Neighboring gene NANOG hESC enhancer GRCh37_chr10:53607630-53608132 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3375 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3376 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:53669244-53670166 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:53674681-53675592 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:53793718-53794412 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:53793022-53793717 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:53798813-53799426 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:53800040-53800652 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:53823712-53824316 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:53824317-53824921 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:53940238-53940738 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:53940739-53941239 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:53945399-53945604 Neighboring gene uncharacterized LOC124902425 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:53964675-53965189 Neighboring gene NANOG hESC enhancer GRCh37_chr10:53973100-53973601 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:53993330-53993927 Neighboring gene PRKG1 antisense RNA 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_119487.1 

    Range
    101..1023
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    51910407..51911329
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    52759524..52760445
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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