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LOC127404763 OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:174988020-174988638 [ Homo sapiens (human) ]

Gene ID: 127404763, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127404763
Gene description
OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:174988020-174988638
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in primed human embryonic stem cells. This enhancer associates with the OCT4 and NANOG transcription factors and is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Oct 2022]
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Genomic context

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See LOC127404763 in Genome Data Viewer
Location:
chromosome: 5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (175561017..175561635)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (176104801..176105419)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (174988020..174988638)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23676 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16644 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr5:174905945-174906540 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:174911541-174912114 Neighboring gene sideroflexin 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:174943953-174945152 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:174960972-174961510 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:174967065-174967566 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:174974284-174975206 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:175023214-175023754 Neighboring gene Sharpr-MPRA regulatory region 8396 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:175044235-175044430 Neighboring gene RN7SK pseudogene 148 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:175065813-175066006 Neighboring gene NANOG hESC enhancer GRCh37_chr5:175076996-175077520 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:175090952-175091530 Neighboring gene histamine receptor H2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:175113560-175114280 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:175114281-175115000 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:175115001-175115720 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:175115721-175116440 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:175117667-175118168 Neighboring gene uncharacterized LOC105377743 Neighboring gene Sharpr-MPRA regulatory region 12912

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_106712.1 

    Range
    101..719
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    175561017..175561635
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    176104801..176105419
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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