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LOC127402861 OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:49436741-49437580 [ Homo sapiens (human) ]

Gene ID: 127402861, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127402861
Gene description
OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:49436741-49437580
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive human embryonic stem cells. This enhancer associates with the OCT4 and NANOG transcription factors and is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Oct 2022]
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Genomic context

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See LOC127402861 in Genome Data Viewer
Location:
chromosome: 5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (50140907..50141746)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (50957310..50958149)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (49436741..49437580)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901180 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:45288792-45289361 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:45385335-45386534 Neighboring gene NANOG hESC enhancer GRCh37_chr5:45398997-45399517 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:45694855-45695356 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:45695357-45695856 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:45722136-45723335 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:45847424-45848170 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:45848171-45848917 Neighboring gene hyperpolarization activated cyclic nucleotide gated potassium channel 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:46322424-46322954 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:46323485-46324014 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:46324015-46324544 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:46339317-46339850 Neighboring gene NANOG hESC enhancer GRCh37_chr5:46362710-46363410 Neighboring gene NANOG hESC enhancer GRCh37_chr5:46382059-46382560 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:49410739-49411304 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:49423237-49423778 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:49422693-49423236 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:49418829-49419370 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:49411305-49411870 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:49428344-49429184 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:49429185-49430023 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:49431703-49432542 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:49432543-49433382 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:49433383-49434222 Neighboring gene NANOG hESC enhancer GRCh37_chr5:49539003-49539504 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22542 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15998 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15999 Neighboring gene peptidylprolyl isomerase A like 4G pseudogene Neighboring gene embigin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_104810.1 

    Range
    101..940
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    50140907..50141746
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    50957310..50958149
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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