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LOC127274489 NANOG-H3K4me1 hESC enhancer GRCh37_chr2:117913522-117914022 [ Homo sapiens (human) ]

Gene ID: 127274489, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127274489
Gene description
NANOG-H3K4me1 hESC enhancer GRCh37_chr2:117913522-117914022
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in primed human embryonic stem cells. This enhancer associates with the NANOG transcription factor and is marked by the H3K4me1 histone modification. [provided by RefSeq, Oct 2022]
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Genomic context

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See LOC127274489 in Genome Data Viewer
Location:
chromosome: 2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (117155946..117156446)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (117587629..117588129)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (117913522..117914022)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene MT-CO1 pseudogene 43 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:117844947-117845535 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:117845536-117846123 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:117885600-117886799 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:117914023-117914523 Neighboring gene RNA, U7 small nuclear 190 pseudogene Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:118036121-118036969 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:118041429-118042061 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:118310958-118311548 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:118380535-118381734 Neighboring gene uncharacterized LOC124907878 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:118561637-118562220 Neighboring gene Sharpr-MPRA regulatory region 195 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:118572589-118573124 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11892 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11893 Neighboring gene DEAD-box helicase 18

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_096339.1 

    Range
    101..601
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    117155946..117156446
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    117587629..117588129
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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