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LOC127272022 H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:234657990-234658756 [ Homo sapiens (human) ]

Gene ID: 127272022, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127272022
Gene description
H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:234657990-234658756
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay (MPRA) in primed human embryonic stem cells, where it is marked by the H3K27ac and H3K4me1 histone modifications. This locus also includes an accessible chromatin subregion that was validated as an enhancer based on its ability to activate an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
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Genomic context

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See LOC127272022 in Genome Data Viewer
Location:
chromosome: 1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (234522244..234523010)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (233912643..233913409)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (234657990..234658756)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:234508390-234509214 Neighboring gene COA6 antisense RNA 1 Neighboring gene cytochrome c oxidase assembly factor 6 Neighboring gene TAR (HIV-1) RNA binding protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1969 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1970 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1971 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1972 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2752 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2753 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2755 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2754 Neighboring gene Sharpr-MPRA regulatory region 12347 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2756 Neighboring gene Sharpr-MPRA regulatory region 10256 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2759 Neighboring gene Sharpr-MPRA regulatory region 14716 Neighboring gene long intergenic non-protein coding RNA 1354 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:234675813-234676316 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:234677690-234678190 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:234678191-234678691 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:234689060-234689267 Neighboring gene Sharpr-MPRA regulatory region 4208 Neighboring gene uncharacterized LOC107985465

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ATAC-STARR-seq reveals transcription factor-bound activators and silencers within chromatin-accessible regions of the human genome. Hansen TJ, et al. Genome Res, 2022 Aug 25. PMID 35858748, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

General gene information

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Other Names

  • ATAC-STARR-seq lymphoblastoid active region 2757

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_093873.1 

    Range
    101..867
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    234522244..234523010
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    233912643..233913409
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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