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LOC127271512 H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:212781729-212782686 [ Homo sapiens (human) ]

Gene ID: 127271512, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127271512
Gene description
H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:212781729-212782686
Gene type
biological region
Feature type(s)
regulatory: enhancer, silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region includes an enhancer that was validated by the ChIP-STARR-seq massively parallel reporter assay (MPRA) in naive human embryonic stem cells, where it is marked by the H3K27ac and H3K4me1 histone modifications. This locus also includes three accessible chromatin subregions, two of which were validated as silencers and one as an enhancer based on their ability to repress or activate an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
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Genomic context

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See LOC127271512 in Genome Data Viewer
Location:
chromosome: 1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (212608387..212609392)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (211853325..211854329)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (212781729..212782734)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372908 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:212687383-212688110 Neighboring gene VISTA enhancer hs2089 Neighboring gene long intergenic non-protein coding RNA 1740 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:212731832-212732569 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2506 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2507 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2508 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_3744 Neighboring gene activating transcription factor 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2509 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:212769225-212770424 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1797 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:212780771-212781728 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1800 Neighboring gene Sharpr-MPRA regulatory region 14805 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:212799247-212799747 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:212803852-212804383 Neighboring gene long intergenic non-protein coding RNA 2773 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1801 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:212810785-212811984 Neighboring gene golgi associated RAB2 interactor family member 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:212819605-212820114 Neighboring gene RFK pseudogene 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ATAC-STARR-seq reveals transcription factor-bound activators and silencers within chromatin-accessible regions of the human genome. Hansen TJ, et al. Genome Res, 2022 Aug 25. PMID 35858748, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

General gene information

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Other Names

  • ATAC-STARR-seq lymphoblastoid active region 2511
  • ATAC-STARR-seq lymphoblastoid silent region 1798
  • ATAC-STARR-seq lymphoblastoid silent region 1799

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_093364.2 

    Range
    101..1106
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    212608387..212609392
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    211853325..211854329
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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