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LOC127268965 OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:44307343-44308331 [ Homo sapiens (human) ]

Gene ID: 127268965, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127268965
Gene description
OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:44307343-44308331
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive human embryonic stem cells. This enhancer associates with the OCT4 and NANOG transcription factors and is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Oct 2022]
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Genomic context

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See LOC127268965 in Genome Data Viewer
Location:
chromosome: 1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (43841671..43842659)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (43712497..43713485)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (44307343..44308331)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ST3 beta-galactoside alpha-2,3-sialyltransferase 3 Neighboring gene uncharacterized LOC124904166 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 791 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:44287043-44288242 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:44299839-44300606 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:44300607-44301374 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:44306354-44307342 Neighboring gene microRNA 6079 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:44323792-44324410 Neighboring gene SHMT1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 925 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:44336631-44337131 Neighboring gene Sharpr-MPRA regulatory region 749 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:44365355-44366213 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:44379389-44380204 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:44386271-44387086 Neighboring gene Sharpr-MPRA regulatory region 11119 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 926 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:44397735-44398235 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 927 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 792 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 793 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:44401004-44401598 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:44401599-44402193 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 795 Neighboring gene artemin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_090826.1 

    Range
    101..1089
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    43841671..43842659
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    43712497..43713485
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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