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LOC127266768 H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:994105-994948 [ Homo sapiens (human) ]

Gene ID: 127266768, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127266768
Gene description
H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:994105-994948
Gene type
biological region
Feature type(s)
regulatory: enhancer, silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region includes an enhancer that was validated by the ChIP-STARR-seq massively parallel reporter assay (MPRA) in primed human embryonic stem cells, where it is marked by the H3K27ac and H3K4me1 histone modifications. This locus also includes an accessible chromatin subregion that was validated as a silencer based on its ability to repress an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
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Genomic context

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See LOC127266768 in Genome Data Viewer
Location:
chromosome: 1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (1058725..1059951)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (488797..490023)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (994105..995331)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:948847-949738 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:949739-950630 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:950916-951136 Neighboring gene ISG15 ubiquitin like modifier Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:956772-957971 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:959156-960132 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:960133-961108 Neighboring gene agrin Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:965235-966104 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:967845-968714 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 22 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:974926-975604 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 23 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 24 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:989815-989997 Neighboring gene uncharacterized LOC100288175 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:995794-996637 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:997280-997780 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 26 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1000356-1000856 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1000857-1001357 Neighboring gene uncharacterized LOC105378948 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 27 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 28 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1004678-1005443 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1009379-1009878 Neighboring gene ring finger protein 223

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ATAC-STARR-seq reveals transcription factor-bound activators and silencers within chromatin-accessible regions of the human genome. Hansen TJ, et al. Genome Res, 2022 Aug 25. PMID 35858748, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

General gene information

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Other Names

  • ATAC-STARR-seq lymphoblastoid silent region 25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_088643.2 

    Range
    101..1327
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    1058725..1059951
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    488797..490023
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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