U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LOC126863044 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr20:48782079-48783278 [ Homo sapiens (human) ]

Gene ID: 126863044, updated on 12-Sep-2024

Summary

Go to the top of the page Help
Gene symbol
LOC126863044
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr20:48782079-48783278
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. [provided by RefSeq, Sep 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See LOC126863044 in Genome Data Viewer
Location:
chromosome: 20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (50165542..50166741)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (51935038..51936241)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (48782079..48783278)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene PEDS1-UBE2V1 readthrough Neighboring gene ubiquitin conjugating enzyme E2 V1 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr20:48715799-48716462 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13013 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18083 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:48730039-48730606 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:48732458-48732614 Neighboring gene plasmanylethanolamine desaturase 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:48754882-48755569 Neighboring gene putative uncharacterized protein CCDC28A-AS1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:48760275-48760910 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13014 Neighboring gene long intergenic non-protein coding RNA 1275 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:48788805-48789306 Neighboring gene long intergenic non-protein coding RNA 1273 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:48795707-48796206 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18084 Neighboring gene CEBPB antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13015 Neighboring gene Sharpr-MPRA regulatory region 92 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13017 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13018 Neighboring gene CCAAT enhancer binding protein beta

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_087541.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    50165542..50166741
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    51935038..51936241
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases