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LOC126860399 BRD4-independent group 4 enhancer GRCh37_chr8:59108481-59109680 [ Homo sapiens (human) ]

Gene ID: 126860399, updated on 12-Sep-2024

Summary

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Gene symbol
LOC126860399
Gene description
BRD4-independent group 4 enhancer GRCh37_chr8:59108481-59109680
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126860399 in Genome Data Viewer
Location:
chromosome: 8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (58195922..58197121)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (58617017..58618216)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (59108481..59109680)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19213 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19214 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:58907533-58908033 Neighboring gene long intergenic non-protein coding RNA 1602 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr8:58926679-58927179 Neighboring gene family with sequence similarity 110 member B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:58978669-58979170 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:59010395-59011058 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:59011059-59011722 Neighboring gene NANOG hESC enhancer GRCh37_chr8:59030663-59031236 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:59034986-59035605 Neighboring gene ribosomal protein L26 pseudogene 26 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:59058363-59058965 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27405 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27406 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19216 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:59085063-59085589 Neighboring gene uncharacterized LOC107986945 Neighboring gene VISTA enhancer hs1364 Neighboring gene long intergenic non-protein coding RNA 3133 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27407 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:59282662-59283206 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:59304090-59304590 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:59304591-59305091 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:59308925-59309426 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:59309427-59309926 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27408 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27409 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27410 Neighboring gene UBX domain protein 2B Neighboring gene PTPN11 pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_084899.1 

    Range
    101..1300
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    58195922..58197121
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    58617017..58618216
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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