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LOC126807437 MED14-independent group 3 enhancer GRCh37_chr5:79968379-79969578 [ Homo sapiens (human) ]

Gene ID: 126807437, updated on 12-Sep-2024

Summary

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Gene symbol
LOC126807437
Gene description
MED14-independent group 3 enhancer GRCh37_chr5:79968379-79969578
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 3 enhancer that depends on the BRD2, BRD4, P300/CBP and CDK7 cofactors, but it has limited or no dependence on the MED14 core Mediator complex subunit. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126807437 in Genome Data Viewer
Location:
chromosome: 5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (80672560..80673759)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (81157470..81158669)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (79968379..79969578)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1337 Neighboring gene Sharpr-MPRA regulatory region 2279 Neighboring gene Sharpr-MPRA regulatory regions 13584 and 3862 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:79950324-79951092 Neighboring gene dihydrofolate reductase Neighboring gene MT-RNR2 like 2 (pseudogene) Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:79963410-79963977 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:79963978-79964546 Neighboring gene MPRA-validated peak5310 silencer Neighboring gene mutS homolog 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:80040756-80040944 Neighboring gene S-phase kinase-associated protein 1-like Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:80043670-80044230 Neighboring gene MPRA-validated peak5311 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22728 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:80142431-80142931 Neighboring gene ribosomal protein S26 pseudogene 27

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_083751.1 

    Range
    101..1300
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    80672560..80673759
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    81157470..81158669
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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