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ZNF441 zinc finger protein 441 [ Homo sapiens (human) ]

Gene ID: 126068, updated on 27-Nov-2024

Summary

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Official Symbol
ZNF441provided by HGNC
Official Full Name
zinc finger protein 441provided by HGNC
Primary source
HGNC:HGNC:20875
See related
Ensembl:ENSG00000197044 AllianceGenome:HGNC:20875
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thyroid (RPKM 4.2), kidney (RPKM 3.1) and 25 other tissues See more
Orthologs
all
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Genomic context

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See ZNF441 in Genome Data Viewer
Location:
19p13.2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (11767000..11784078)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (11895201..11912279)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (11877815..11894893)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11785131-11785688 Neighboring gene zinc finger protein 833, pseudogene Neighboring gene CRISPRi-validated cis-regulatory element chr19.1989 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10126 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10127 Neighboring gene zinc finger protein 823 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14031 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10128 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14032 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:11849745-11849939 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14033 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10129 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10130 Neighboring gene uncharacterized LOC124904639 Neighboring gene MPRA-validated peak3359 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10131 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11908593-11909104 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14034 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14035 Neighboring gene zinc finger protein 491 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10132 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10133 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10134 Neighboring gene zinc finger protein 440

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells. Chang YJ, et al. Int J Mol Sci, 2023 Jun 6. PMID 37372979, Free PMC Article
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614, Free PMC Article
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
  4. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ38637

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 441

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152355.3 → NP_689568.2  zinc finger protein 441

    See identical proteins and their annotated locations for NP_689568.2

    Status: VALIDATED

    Source sequence(s)
    AC008543, BX649086, DB250168
    Consensus CDS
    CCDS12266.2
    UniProtKB/Swiss-Prot
    Q8N8Z8
    Related
    ENSP00000350576.4, ENST00000357901.5
    Conserved Domains (5) summary
    smart00349
    Location:4 → 44
    KRAB; krueppel associated box
    COG5048
    Location:222 → 634
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:589 → 609
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4 → 40
    KRAB; KRAB box
    pfam13465
    Location:601 → 626
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    11767000..11784078
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    11895201..11912279
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N8Z8.2 GenPept UniProtKB/Swiss-Prot:Q8N8Z8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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