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Ctla4 cytotoxic T-lymphocyte-associated protein 4 [ Mus musculus (house mouse) ]

Gene ID: 12477, updated on 27-Nov-2024

Summary

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Official Symbol
Ctla4provided by MGI
Official Full Name
cytotoxic T-lymphocyte-associated protein 4provided by MGI
Primary source
MGI:MGI:88556
See related
Ensembl:ENSMUSG00000026011 AllianceGenome:MGI:88556
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cd152; Ly-56; Ctla-4
Summary
This gene is a member of the immunoglobulin superfamily, and encodes a protein that functions as a negative regulator of T-cell responses. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2013]
Expression
Biased expression in thymus adult (RPKM 1.4), spleen adult (RPKM 0.8) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Ctla4 in Genome Data Viewer
Location:
1 C2; 1 30.58 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (60948184..60954991)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (60909025..60915832)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39650 Neighboring gene STARR-positive B cell enhancer ABC_E8981 Neighboring gene STARR-positive B cell enhancer ABC_E1547 Neighboring gene ribosomal protein L18, pseudogene 1 Neighboring gene predicted gene, 34649 Neighboring gene dynein light chain LC8-type 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Poxvirus-based active immunotherapy synergizes with CTLA-4 blockade to increase survival in a murine tumor model by improving the magnitude and quality of cytotoxic T cells. Foy SP, et al. Cancer Immunol Immunother, 2016 May. PMID 26961085, Free PMC Article
  2. The soluble CTLA-4 splice variant protects from type 1 diabetes and potentiates regulatory T-cell function. Gerold KD, et al. Diabetes, 2011 Jul. PMID 21602513, Free PMC Article
  3. CTLA-4 signaling regulates the intensity of hypersensitivity responses to food antigens, but is not decisive in the induction of sensitization. van Wijk F, et al. J Immunol, 2005 Jan 1. PMID 15611239
  4. CTLA-4 engagement acts as a brake on CD4+ T cell proliferation and cytokine production but is not required for tuning T cell reactivity in adaptive tolerance. Inobe M, et al. J Immunol, 2004 Dec 15. PMID 15585846
  5. Role of CTLA-4 in the activation of single- and double-positive thymocytes. Kwon H, et al. J Immunol, 2004 Dec 1. PMID 15557155

See all (391) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. High PD-1 and CTLA-4 expression correlates with host immune suppression in patients and a mouse model infected with Echinococcus multilocularis.
    Title: High PD-1 and CTLA-4 expression correlates with host immune suppression in patients and a mouse model infected with Echinococcus multilocularis.
  2. Rapid turnover of CTLA4 is associated with a complex architecture of reversible ubiquitylation.
    Title: Rapid turnover of CTLA4 is associated with a complex architecture of reversible ubiquitylation.
  3. CTLA-4-expressing ILC3s restrain interleukin-23-mediated inflammation.
    Title: CTLA-4-expressing ILC3s restrain interleukin-23-mediated inflammation.
  4. PD-1 or CTLA-4 blockade promotes CD86-driven Treg responses upon radiotherapy of lymphocyte-depleted cancer in mice.
    Title: PD-1 or CTLA-4 blockade promotes CD86-driven Treg responses upon radiotherapy of lymphocyte-depleted cancer in mice.
  5. Soluble CTLA-4 attenuates T cell activation and modulates anti-tumor immunity.
    Title: Soluble CTLA-4 attenuates T cell activation and modulates anti-tumor immunity.
  6. IFNgamma and CTLA-4 Drive Hepatic CD4 T-Cell Tolerance and Protection From Autoimmunity in Mice.
    Title: IFNγ and CTLA-4 Drive Hepatic CD4 T-Cell Tolerance and Protection From Autoimmunity in Mice.
  7. DECTIN-1: A modifier protein in CTLA-4 haploinsufficiency.
    Title: DECTIN-1: A modifier protein in CTLA-4 haploinsufficiency.
  8. The OX40-TRAF6 axis promotes CTLA-4 degradation to augment antitumor CD8[+] T-cell immunity.
    Title: The OX40-TRAF6 axis promotes CTLA-4 degradation to augment antitumor CD8(+) T-cell immunity.
  9. CTLA4-Ig alleviates the allogeneic immune responses against insulin-producing cells in a murine model of cell transplantation.
    Title: CTLA4-Ig alleviates the allogeneic immune responses against insulin-producing cells in a murine model of cell transplantation.
  10. CTLA-4 suppresses hapten-induced contact hypersensitivity in atopic dermatitis model mice.
    Title: CTLA-4 suppresses hapten-induced contact hypersensitivity in atopic dermatitis model mice.
Submit: New GeneRIF Correction See all GeneRIFs (202)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (13) 
  • Targeted (7)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in B cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in B cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of B cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of regulatory T cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of regulatory T cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of T cell proliferation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in clathrin-coated endocytic vesicle ISO
Inferred from Sequence Orthology
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of protein complex involved in cell adhesion ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
cytotoxic T-lymphocyte protein 4
Names
CD152 antigen
cytotoxic T-lymphocyte-associated antigen 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001281976.1 → NP_001268905.1  cytotoxic T-lymphocyte protein 4 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001268905.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks the penultimate coding exon, which results in a frame-shift and early translation termination compared to variant 1. The resulting shorter isoform (2, also known as sCTLA-4) with a distinct C-terminus, lacks the transmembrane domain and is secreted (PMIDs: 10831323, 23400950).
    Source sequence(s)
    AI323635, AK138891, AL663047
    Consensus CDS
    CCDS69893.1
    UniProtKB/TrEMBL
    Q5SSM0
    Related
    ENSMUSP00000095327.4, ENSMUST00000097720.4
    Conserved Domains (2) summary
    cd05721
    Location:39 → 152
    IgV_CTLA-4; Immunoglobulin (Ig) domain of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)
    smart00410
    Location:43 → 132
    IG_like; Immunoglobulin like

  2. NM_009843.4 → NP_033973.2  cytotoxic T-lymphocyte protein 4 isoform 1 precursor

    See identical proteins and their annotated locations for NP_033973.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer membrane-bound isoform (1).
    Source sequence(s)
    AI323635, AK138891, AL663047
    Consensus CDS
    CCDS14993.1
    UniProtKB/Swiss-Prot
    P09793, Q9QZZ7
    UniProtKB/TrEMBL
    Q6GTR6, Q7TMX1
    Related
    ENSMUSP00000027164.3, ENSMUST00000027164.9
    Conserved Domains (2) summary
    cd05721
    Location:39 → 152
    IgV_CTLA-4; Immunoglobulin (Ig) domain of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)
    smart00410
    Location:43 → 132
    IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    60948184..60954991
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156357.1 → XP_036012250.1  cytotoxic T-lymphocyte protein 4 isoform X1

    Conserved Domains (2) summary
    cd00096
    Location:1 → 9
    Ig; Ig strand C' [structural motif]
    cl11960
    Location:1 → 73
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P09793.1 GenPept UniProtKB/Swiss-Prot:P09793

Gene LinkOut

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