Casr calcium-sensing receptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Casrprovided by MGI
Official Full Name: calcium-sensing receptorprovided by MGI
Primary source: MGI:MGI:1351351
See related: Ensembl:ENSMUSG00000051980 AllianceGenome:MGI:1351351
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CaR; Gprc2a
Summary: Predicted to enable several functions, including integrin binding activity; protein homodimerization activity; and transmembrane transporter binding activity. Involved in regulation of presynaptic membrane potential. Acts upstream of or within positive regulation of ATP-dependent activity; positive regulation of gene expression; and regulation of calcium ion transport. Is active in glutamatergic synapse. Is expressed in several structures, including branchial pouch; central nervous system; lung; metanephros; and superior cervical ganglion. Used to study autosomal dominant hypocalcemia 1; familial hypocalciuric hypercalcemia 1; and hyperparathyroidism. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant hypocalcemia (multiple); hypercalcemia (multiple); hyperparathyroidism (multiple); idiopathic generalized epilepsy 8; and nephrolithiasis (multiple). Orthologous to human CASR (calcium sensing receptor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in kidney adult (RPKM 6.6) and mammary gland adult (RPKM 0.5) See more
Orthologs: human all
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Genomic context

Location:: 16 B3; 16 25.57 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (36310947..36382605, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (36490585..36562141, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The calcium-sensing-receptor (CaSR) in adipocytes contributes to sex-differences in the susceptibility to high fat diet induced obesity and atherosclerosis.
Title: The calcium-sensing-receptor (CaSR) in adipocytes contributes to sex-differences in the susceptibility to high fat diet induced obesity and atherosclerosis.
A novel mouse model for familial hypocalciuric hypercalcemia (FHH1) reveals PTH-dependent and independent CaSR defects.
Title: A novel mouse model for familial hypocalciuric hypercalcemia (FHH1) reveals PTH-dependent and independent CaSR defects.
Alterations in gene expression and microbiome composition upon calcium-sensing receptor deletion in the mouse esophagus.
Title: Alterations in gene expression and microbiome composition upon calcium-sensing receptor deletion in the mouse esophagus.
Calcium/calcimimetic via calcium-sensing receptor ameliorates cholera toxin-induced secretory diarrhea in mice.
Title: Calcium/calcimimetic via calcium-sensing receptor ameliorates cholera toxin-induced secretory diarrhea in mice.
CaSR modulates proliferation of the superficial zone cells in temporomandibular joint cartilage via the PTHrP nuclear localization sequence.
Title: CaSR modulates proliferation of the superficial zone cells in temporomandibular joint cartilage via the PTHrP nuclear localization sequence.
Role of calcium-sensing receptor in regulating activation susceptibility of postovulatory aging mouse oocytes.
Title: Role of calcium-sensing receptor in regulating activation susceptibility of postovulatory aging mouse oocytes.
Calcium-Sensing Receptor Negative Allosteric Modulators Oppose Contraction of Mouse Airways.
Title: Calcium-Sensing Receptor Negative Allosteric Modulators Oppose Contraction of Mouse Airways.
The CaSR/TRPV4 coupling mediates pro-inflammatory macrophage function.
Title: The CaSR/TRPV4 coupling mediates pro-inflammatory macrophage function.
Calcium-sensing receptor and CPAP-induced neonatal airway hyperreactivity in mice.
Title: Calcium-sensing receptor and CPAP-induced neonatal airway hyperreactivity in mice.
Ap2s1 mutation causes hypercalcaemia in mice and impairs interaction between calcium-sensing receptor and adaptor protein-2.
Title: Ap2s1 mutation causes hypercalcaemia in mice and impairs interaction between calcium-sensing receptor and adaptor protein-2.

Submit: New GeneRIF Correction See all GeneRIFs (110)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (6) 1 citation
Chemically induced (other) (1) 1 citation
Endonuclease-mediated (7)
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Casr (e-PCR), detects polymorphism
- UniSTS:506683

Casr (e-PCR), detects polymorphism
- UniSTS:516195

Casr (e-PCR), detects polymorphism
- UniSTS:516196

Casr (e-PCR), detects polymorphism
- UniSTS:545907

Casr (e-PCR), detects polymorphism
- UniSTS:526210

AF110178 (e-PCR)
- UniSTS:180905

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables amino acid binding	ISO Inferred from Sequence Orthology more info
enables amino acid binding	ISS Inferred from Sequence or Structural Similarity more info
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	IEA Inferred from Electronic Annotation more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in bile acid secretion	IEA Inferred from Electronic Annotation more info
involved_in bile acid secretion	ISO Inferred from Sequence Orthology more info
involved_in branching morphogenesis of an epithelial tube	IEA Inferred from Electronic Annotation more info
involved_in branching morphogenesis of an epithelial tube	ISO Inferred from Sequence Orthology more info
involved_in calcium ion import	IEA Inferred from Electronic Annotation more info
involved_in calcium ion import	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucose stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hepatocyte growth factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in cellular response to low-density lipoprotein particle stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to peptide	IEA Inferred from Electronic Annotation more info
involved_in cellular response to vitamin D	IEA Inferred from Electronic Annotation more info
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in chloride transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in detection of calcium ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in detection of calcium ion	ISO Inferred from Sequence Orthology more info
involved_in detection of calcium ion	ISS Inferred from Sequence or Structural Similarity more info
involved_in fat pad development	IEA Inferred from Electronic Annotation more info
involved_in intracellular calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular calcium ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in ossification	IEA Inferred from Electronic Annotation more info
involved_in ossification	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of ATP-dependent activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of ATP-dependent activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion import	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of calcium ion import	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of insulin secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of positive chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of positive chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vasoconstriction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vasoconstriction	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium ion transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of presynaptic membrane potential	EXP Inferred from Experiment more info	PubMed
involved_in regulation of presynaptic membrane potential	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of presynaptic membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to fibroblast growth factor	IEA Inferred from Electronic Annotation more info
involved_in response to ischemia	IEA Inferred from Electronic Annotation more info
involved_in vasodilation	IEA Inferred from Electronic Annotation more info
involved_in vasodilation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axon terminus	IEA Inferred from Electronic Annotation more info
located_in axon terminus	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in presynaptic membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: extracellular calcium-sensing receptor

Names: G protein-coupled receptor, family C, group 2, member A; PCaR1; cation sensing receptor; parathyroid cell calcium-sensing receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013803.3 → NP_038831.2 extracellular calcium-sensing receptor precursor

See identical proteins and their annotated locations for NP_038831.2

Status: VALIDATED

Source sequence(s)

AC074229, AF110178

Consensus CDS

CCDS28154.1

UniProtKB/Swiss-Prot

G3UX06, O08968, O88519, Q9QY95, Q9QY96, Q9QZU8, Q9R1D6, Q9R1Y2

Related

ENSMUSP00000069080.8, ENSMUST00000063597.14

Conserved Domains (3) summary

cd15282
Location:611 → 862

7tmC_CaSR; calcium-sensing receptor, member of the class C of seven-transmembrane G protein-coupled receptors

cd06364
Location:33 → 530

PBP1_CaSR; ligand-binding domain of the CaSR calcium-sensing receptor, a member of the family C receptors within the G-protein coupled receptor superfamily

pfam07562
Location:538 → 591

NCD3G; Nine Cysteines Domain of family 3 GPCR

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

36310947..36382605 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006521730.3 → XP_006521793.1 extracellular calcium-sensing receptor isoform X1

See identical proteins and their annotated locations for XP_006521793.1

UniProtKB/Swiss-Prot

G3UX06, O08968, O88519, Q9QY95, Q9QY96, Q9QZU8, Q9R1D6, Q9R1Y2

Conserved Domains (3) summary

cd15282
Location:611 → 862

7tmC_CaSR; calcium-sensing receptor, member of the class C of seven-transmembrane G protein-coupled receptors

cd06364
Location:33 → 530

PBP1_CaSR; ligand-binding domain of the CaSR calcium-sensing receptor, a member of the family C receptors within the G-protein coupled receptor superfamily

pfam07562
Location:538 → 591

NCD3G; Nine Cysteines Domain of family 3 GPCR
XM_036159757.1 → XP_036015650.1 extracellular calcium-sensing receptor isoform X1

UniProtKB/Swiss-Prot

G3UX06, O08968, O88519, Q9QY95, Q9QY96, Q9QZU8, Q9R1D6, Q9R1Y2

Conserved Domains (3) summary

cd15282
Location:611 → 862

7tmC_CaSR; calcium-sensing receptor, member of the class C of seven-transmembrane G protein-coupled receptors

cd06364
Location:33 → 530

PBP1_CaSR; ligand-binding domain of the CaSR calcium-sensing receptor, a member of the family C receptors within the G-protein coupled receptor superfamily

pfam07562
Location:538 → 591

NCD3G; Nine Cysteines Domain of family 3 GPCR
XM_006521731.5 → XP_006521794.1 extracellular calcium-sensing receptor isoform X1

See identical proteins and their annotated locations for XP_006521794.1

UniProtKB/Swiss-Prot

G3UX06, O08968, O88519, Q9QY95, Q9QY96, Q9QZU8, Q9R1D6, Q9R1Y2

Related

ENSMUSP00000133500.2, ENSMUST00000172826.2

Conserved Domains (3) summary

cd15282
Location:611 → 862

7tmC_CaSR; calcium-sensing receptor, member of the class C of seven-transmembrane G protein-coupled receptors

cd06364
Location:33 → 530

PBP1_CaSR; ligand-binding domain of the CaSR calcium-sensing receptor, a member of the family C receptors within the G-protein coupled receptor superfamily

pfam07562
Location:538 → 591

NCD3G; Nine Cysteines Domain of family 3 GPCR
XM_006521732.3 → XP_006521795.1 extracellular calcium-sensing receptor isoform X1

See identical proteins and their annotated locations for XP_006521795.1

UniProtKB/Swiss-Prot

G3UX06, O08968, O88519, Q9QY95, Q9QY96, Q9QZU8, Q9R1D6, Q9R1Y2

Conserved Domains (3) summary

cd15282
Location:611 → 862

7tmC_CaSR; calcium-sensing receptor, member of the class C of seven-transmembrane G protein-coupled receptors

cd06364
Location:33 → 530

PBP1_CaSR; ligand-binding domain of the CaSR calcium-sensing receptor, a member of the family C receptors within the G-protein coupled receptor superfamily

pfam07562
Location:538 → 591

NCD3G; Nine Cysteines Domain of family 3 GPCR
XM_006521729.3 → XP_006521792.1 extracellular calcium-sensing receptor isoform X1

See identical proteins and their annotated locations for XP_006521792.1

UniProtKB/Swiss-Prot

G3UX06, O08968, O88519, Q9QY95, Q9QY96, Q9QZU8, Q9R1D6, Q9R1Y2

Conserved Domains (3) summary

cd15282
Location:611 → 862

7tmC_CaSR; calcium-sensing receptor, member of the class C of seven-transmembrane G protein-coupled receptors

cd06364
Location:33 → 530

PBP1_CaSR; ligand-binding domain of the CaSR calcium-sensing receptor, a member of the family C receptors within the G-protein coupled receptor superfamily

pfam07562
Location:538 → 591

NCD3G; Nine Cysteines Domain of family 3 GPCR