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TARS3 threonyl-tRNA synthetase 3 [ Homo sapiens (human) ]

Gene ID: 123283, updated on 27-Nov-2024

Summary

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Official Symbol
TARS3provided by HGNC
Official Full Name
threonyl-tRNA synthetase 3provided by HGNC
Primary source
HGNC:HGNC:24728
See related
Ensembl:ENSG00000185418 AllianceGenome:HGNC:24728
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TARSL2; ThrRS-L
Summary
Predicted to enable threonine-tRNA ligase activity. Predicted to be involved in threonyl-tRNA aminoacylation. Predicted to be located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in brain (RPKM 4.4), heart (RPKM 3.4) and 25 other tissues See more
Orthologs
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Genomic context

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See TARS3 in Genome Data Viewer
Location:
15q26.3
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (101653596..101724473, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (99411600..99482344, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (102193799..102264676, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:102152533-102153033 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:102153852-102154370 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:102154371-102154887 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:102157328-102157940 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6891 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:102186842-102187008 Neighboring gene TM2 domain containing 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6892 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10195 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:102192988-102193878 Neighboring gene RNA, U6 small nuclear 807, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:102215750-102216274 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:102216275-102216797 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6894 Neighboring gene UBE2Q2 pseudogene 13 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:102286622-102286992 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr15:102303375-102304574 Neighboring gene dynamin 1 pseudogene 47

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Newly acquired N-terminal extension targets threonyl-tRNA synthetase-like protein into the multiple tRNA synthetase complex. Zhou XL, et al. Nucleic Acids Res, 2019 Sep 19. PMID 31287872, Free PMC Article
  2. miR-720 is a key regulator of glioma migration and invasion by controlling TARSL2 expression. Liu Y, et al. Hum Cell, 2021 Sep. PMID 34024034
  3. A threonyl-tRNA synthetase-like protein has tRNA aminoacylation and editing activities. Chen Y, et al. Nucleic Acids Res, 2018 Apr 20. PMID 29579307, Free PMC Article
  4. Reinvestigation of aminoacyl-tRNA synthetase core complex by affinity purification-mass spectrometry reveals TARSL2 as a potential member of the complex. Kim K, et al. PLoS One, 2013. PMID 24312579, Free PMC Article
  5. VHL negatively regulates SARS coronavirus replication by modulating nsp16 ubiquitination and stability. Yu X, et al. Biochem Biophys Res Commun, 2015 Apr 3. PMID 25732088, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. miR-720 is a key regulator of glioma migration and invasion by controlling TARSL2 expression.
    Title: miR-720 is a key regulator of glioma migration and invasion by controlling TARSL2 expression.
  2. Newly acquired N-terminal extension targets threonyl-tRNA synthetase-like protein into the multiple tRNA synthetase complex.
    Title: Newly acquired N-terminal extension targets threonyl-tRNA synthetase-like protein into the multiple tRNA synthetase complex.
  3. TARSL2 is potentially a new component of aminoacyl-tRNA synthetase core-complex
    Title: Reinvestigation of aminoacyl-tRNA synthetase core complex by affinity purification-mass spectrometry reveals TARSL2 as a potential member of the complex.
  4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ25005

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables threonine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables threonine-tRNA ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in threonyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in threonyl-tRNA aminoacylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
threonine--tRNA ligase 2, cytoplasmic
Names
probable threonine--tRNA ligase 2, cytoplasmic
probable threonyl-tRNA synthetase 2, cytoplasmic
thrRS
threonyl-tRNA synthetase like 2
threonyl-tRNA synthetase protein 3
threonyl-tRNA synthetase-like protein 2
NP_689547.2
XP_016877401.1
XP_047288096.1
XP_047288098.1
XP_054233241.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152334.3 → NP_689547.2  threonine--tRNA ligase 2, cytoplasmic

    See identical proteins and their annotated locations for NP_689547.2

    Status: VALIDATED

    Source sequence(s)
    AC027559, AC090164, AK056653, AL833188, AW161214, BE856588, BU677165
    Consensus CDS
    CCDS10394.1
    UniProtKB/Swiss-Prot
    A2RTX5, B2RMP7, Q6B0A1, Q6IS76, Q96LW3, Q96MP4
    UniProtKB/TrEMBL
    B7ZLP8
    Related
    ENSP00000338093.3, ENST00000335968.8
    Conserved Domains (5) summary
    cd01667
    Location:162 → 223
    TGS_ThrRS_N; TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and ...
    PLN02908
    Location:122 → 795
    PLN02908; threonyl-tRNA synthetase
    smart00863
    Location:329 → 376
    tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain
    cd00771
    Location:400 → 697
    ThrRS_core; Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...
    cd00860
    Location:697 → 788
    ThrRS_anticodon; ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    101653596..101724473 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047432142.1 → XP_047288098.1  threonine--tRNA ligase 2, cytoplasmic isoform X3

  2. XM_047432140.1 → XP_047288096.1  threonine--tRNA ligase 2, cytoplasmic isoform X1

    Related
    ENSP00000478827.1, ENST00000615656.1

  3. XM_017021912.3 → XP_016877401.1  threonine--tRNA ligase 2, cytoplasmic isoform X2

    UniProtKB/TrEMBL
    B7ZLP8
    Conserved Domains (1) summary
    PLN02908
    Location:122 → 655
    PLN02908; threonyl-tRNA synthetase

RNA

  1. XR_007064422.1 RNA Sequence

  2. XR_931749.4 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    99411600..99482344 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054377266.1 → XP_054233241.1  threonine--tRNA ligase 2, cytoplasmic isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2RTX5.1 GenPept UniProtKB/Swiss-Prot:A2RTX5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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