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Cacna1b calcium channel, voltage-dependent, N type, alpha 1B subunit [ Mus musculus (house mouse) ]

Gene ID: 12287, updated on 27-Nov-2024

Summary

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Official Symbol
Cacna1bprovided by MGI
Official Full Name
calcium channel, voltage-dependent, N type, alpha 1B subunitprovided by MGI
Primary source
MGI:MGI:88296
See related
Ensembl:ENSMUSG00000004113 AllianceGenome:MGI:88296
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BIII; Cav2.2; Cchn1a; alpha(1B)
Summary
Enables high voltage-gated calcium channel activity. Acts upstream of or within several processes, including calcium ion transmembrane transport; neurotransmitter secretion; and response to pain. Located in dendrite; membrane; and neuronal cell body. Part of voltage-gated calcium channel complex. Is active in presynaptic active zone. Is expressed in several structures, including adrenal gland; alimentary system; brain; genitourinary system; and retina. Human ortholog(s) of this gene implicated in Lambert-Eaton myasthenic syndrome. Orthologous to human CACNA1B (calcium voltage-gated channel subunit alpha1 B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in CNS E18 (RPKM 11.3), whole brain E14.5 (RPKM 9.4) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Cacna1b in Genome Data Viewer
Location:
2 A3; 2 16.58 cM
Exon count:
51
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (24493872..24653210, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (24603860..24763200, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene Pax8 CNS1 enhancer Neighboring gene predicted gene, 39769 Neighboring gene Pax8 CNS87 enhancer Neighboring gene WW domain containing E3 ubiquitin protein ligase 1 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:24603469-24603689 Neighboring gene euchromatic histone methyltransferase 1 Neighboring gene STARR-positive B cell enhancer mm9_chr2:24766046-24766347 Neighboring gene STARR-positive B cell enhancer ABC_E634 Neighboring gene arrestin domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Increased expression of P/Q-type Ca2+ channel alpha1A subunit mRNA in cerebellum of N-type Ca2+ channel alpha1B subunit gene-deficient mice. Takahashi E, et al. Brain Res Mol Brain Res, 2004 Apr 29. PMID 15093688
  2. Attenuation of renal fibrosis after unilateral ureteral obstruction in mice lacking the N-type calcium channel. Mishima K, et al. PLoS One, 2019. PMID 31596895, Free PMC Article
  3. Modified sympathetic regulation in N-type calcium channel null-mouse. Murakami M, et al. Biochem Biophys Res Commun, 2007 Mar 23. PMID 17275790
  4. Increased sensitivity to halothane but decreased sensitivity to propofol in mice lacking the N-type Ca2+ channel. Takei T, et al. Neurosci Lett, 2003 Oct 16. PMID 12962913
  5. Ablation of α(2)δ-1 inhibits cell-surface trafficking of endogenous N-type calcium channels in the pain pathway in vivo. Nieto-Rostro M, et al. Proc Natl Acad Sci U S A, 2018 Dec 18. PMID 30487217, Free PMC Article

See all (128) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Interleukin-1alpha links peripheral CaV2.2 channel activation to rapid adaptive increases in heat sensitivity in skin.
    Title: Interleukin-1α links peripheral Ca(V)2.2 channel activation to rapid adaptive increases in heat sensitivity in skin.
  2. Cav2.2 Channels Sustain Vesicle Recruitment at a Mature Glutamatergic Synapse.
    Title: Ca(v)2.2 Channels Sustain Vesicle Recruitment at a Mature Glutamatergic Synapse.
  3. N-type calcium channel v2.2 is a target of TCF21 in adrenocortical carcinomas.
    Title: N-type calcium channel v2.2 is a target of TCF21 in adrenocortical carcinomas.
  4. Constitutive activity of dopamine receptor type 1 (D1R) increases CaV2.2 currents in PFC neurons.
    Title: Constitutive activity of dopamine receptor type 1 (D1R) increases CaV2.2 currents in PFC neurons.
  5. Knockdown of microglial Cav2.2 N-type voltage-dependent Ca(2+) channel ameliorates behavioral deficits in a mouse model of Parkinson's disease.
    Title: Knockdown of microglial Cav2.2 N-type voltage-dependent Ca(2+) channel ameliorates behavioral deficits in a mouse model of Parkinson's disease.
  6. Involvement of N-type Ca(2+) channel in microglial activation and its implications to aging-induced exaggerated cytokine response.
    Title: Involvement of N-type Ca(2+) channel in microglial activation and its implications to aging-induced exaggerated cytokine response.
  7. alternative splicing of Cacna1b e37a influences excitatory transmitter release and couples to complex behaviors.
    Title: Cacna1b alternative splicing impacts excitatory neurotransmission and is linked to behavioral responses to aversive stimuli.
  8. Co-immunoprecipitations from brain tissue is consistent with the formation of a protein complex between RB-3alpha and RB-3beta and both Cav2.2 and the related Cav2.1 calcium channel.
    Title: Interactions of Rabconnectin-3 with Cav2 calcium channels.
  9. The studies and identified +e18a-Cacna1b mRNA in deep cerebellar cells and spinal cord motor neurons and +e18a-Cacna1b is enriched in cholecystokinin-expressing interneurons.
    Title: Tissue- and cell-specific expression of a splice variant in the II-III cytoplasmic loop of Cacna1b.
  10. Munc13-3 regulates the density of Cav2.1 and Cav2.2 channels, alters the localization of Cav2.1, and is required for the development of tight, nanodomain coupling at parallel-fiber active zones.
    Title: Munc13-3 Is Required for the Developmental Localization of Ca(2+) Channels to Active Zones and the Nanopositioning of Ca(v)2.1 Near Release Sensors.
Submit: New GeneRIF Correction See all GeneRIFs (40)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables high voltage-gated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables high voltage-gated calcium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables high voltage-gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase 2A binding ISO
Inferred from Sequence Orthology
more info
  
enables voltage-gated calcium channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables voltage-gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in calcium ion import ISO
Inferred from Sequence Orthology
more info
  
involved_in calcium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within calcium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within calcium ion transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in calcium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neurotransmitter secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of neurotransmitter secretion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of calcium ion transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of calcium-dependent activation of synaptic vesicle fusion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of heart contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to amyloid-beta ISO
Inferred from Sequence Orthology
more info
  
involved_in response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to pain IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to testosterone ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
  
located_in axon terminus ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendritic shaft ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynaptic active zone IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
part_of voltage-gated calcium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated calcium channel complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
voltage-dependent N-type calcium channel subunit alpha-1B
Names
brain calcium channel III
calcium channel, L type, alpha-1 polypeptide
calcium channel, voltage-dependent, L type, alpha 1B subunit
calcium channel, voltage-dependent, N type, alpha 1B subunit, BIII
voltage-gated calcium channel subunit alpha Cav2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042528.3 → NP_001035993.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform 1

    See identical proteins and their annotated locations for NP_001035993.1

    Status: VALIDATED

    Source sequence(s)
    AL732525, AL732546, BX294112
    Consensus CDS
    CCDS38065.1
    UniProtKB/Swiss-Prot
    O55017, Q60609
    UniProtKB/TrEMBL
    A2AIR7
    Related
    ENSMUSP00000037416.6, ENSMUST00000041342.12
    Conserved Domains (3) summary
    pfam00520
    Location:1481 → 1710
    Ion_trans; Ion transport protein
    pfam08763
    Location:1784 → 1858
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:1718 → 1782
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  2. NM_007579.4 → NP_031605.2  voltage-dependent N-type calcium channel subunit alpha-1B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL732525, AL732546, BX294112
    Consensus CDS
    CCDS15739.1
    UniProtKB/TrEMBL
    A2AIR7, A2AIS0
    Related
    ENSMUSP00000063236.8, ENSMUST00000070864.14
    Conserved Domains (3) summary
    pfam00520
    Location:1476 → 1707
    Ion_trans; Ion transport protein
    pfam08763
    Location:1781 → 1819
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:1715 → 1779
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    24493872..24653210 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497635.4 → XP_006497698.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X13

    UniProtKB/TrEMBL
    A2AIR7
    Conserved Domains (4) summary
    PHA03307
    Location:1884 → 2251
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01271
    Location:936 → 1041
    Granin; Granin (chromogranin or secretogranin)
    pfam00520
    Location:94 → 367
    Ion_trans; Ion transport protein
    pfam08763
    Location:1733 → 1807
    Ca_chan_IQ; Voltage gated calcium channel IQ domain

  2. XM_006497634.3 → XP_006497697.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X12

    UniProtKB/TrEMBL
    A2AIR7
    Conserved Domains (5) summary
    PHA03307
    Location:1932 → 2299
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01271
    Location:913 → 1018
    Granin; Granin (chromogranin or secretogranin)
    pfam00520
    Location:1458 → 1707
    Ion_trans; Ion transport protein
    pfam08763
    Location:1781 → 1855
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:1716 → 1769
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  3. XM_006497632.3 → XP_006497695.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X10

    UniProtKB/TrEMBL
    A2AIR7, A2AIR9
    Related
    ENSMUSP00000100003.3, ENSMUST00000102939.9
    Conserved Domains (5) summary
    PHA03307
    Location:1933 → 2300
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01271
    Location:914 → 1019
    Granin; Granin (chromogranin or secretogranin)
    pfam00520
    Location:1459 → 1708
    Ion_trans; Ion transport protein
    pfam08763
    Location:1782 → 1856
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:1717 → 1770
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  4. XM_017315156.1 → XP_017170645.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X18

    UniProtKB/TrEMBL
    A2AIR7
    Conserved Domains (5) summary
    PHA03307
    Location:1952 → 2319
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01271
    Location:935 → 1040
    Granin; Granin (chromogranin or secretogranin)
    pfam00520
    Location:1480 → 1727
    Ion_trans; Ion transport protein
    pfam08763
    Location:1801 → 1875
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:1736 → 1789
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  5. XM_017315140.1 → XP_017170629.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X3

    UniProtKB/TrEMBL
    A2AIR7
    Conserved Domains (5) summary
    PHA03307
    Location:1958 → 2325
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01271
    Location:935 → 1040
    Granin; Granin (chromogranin or secretogranin)
    pfam00520
    Location:1484 → 1733
    Ion_trans; Ion transport protein
    pfam08763
    Location:1807 → 1881
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:1742 → 1795
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  6. XM_017315146.1 → XP_017170635.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X9

    UniProtKB/TrEMBL
    A2AIR7
    Conserved Domains (5) summary
    PHA03307
    Location:1937 → 2304
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01271
    Location:914 → 1019
    Granin; Granin (chromogranin or secretogranin)
    pfam00520
    Location:1463 → 1712
    Ion_trans; Ion transport protein
    pfam08763
    Location:1786 → 1860
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:1721 → 1774
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  7. XM_006497633.3 → XP_006497696.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X11

    UniProtKB/TrEMBL
    A2AIR7
    Conserved Domains (5) summary
    PHA03307
    Location:1932 → 2299
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01271
    Location:915 → 1020
    Granin; Granin (chromogranin or secretogranin)
    pfam00520
    Location:1460 → 1707
    Ion_trans; Ion transport protein
    pfam08763
    Location:1781 → 1855
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:1716 → 1769
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  8. XM_006497631.3 → XP_006497694.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X8

    UniProtKB/TrEMBL
    A2AIR7
    Conserved Domains (5) summary
    PHA03307
    Location:1938 → 2305
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01271
    Location:915 → 1020
    Granin; Granin (chromogranin or secretogranin)
    pfam00520
    Location:1464 → 1713
    Ion_trans; Ion transport protein
    pfam08763
    Location:1787 → 1861
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:1722 → 1775
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  9. XM_006497629.3 → XP_006497692.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X6

    UniProtKB/TrEMBL
    A2AIR7
    Conserved Domains (5) summary
    PHA03307
    Location:1954 → 2321
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01271
    Location:935 → 1040
    Granin; Granin (chromogranin or secretogranin)
    pfam00520
    Location:1480 → 1729
    Ion_trans; Ion transport protein
    pfam08763
    Location:1803 → 1877
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:1738 → 1791
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  10. XM_006497627.3 → XP_006497690.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X2

    UniProtKB/TrEMBL
    A2AIR7
    Conserved Domains (5) summary
    PHA03307
    Location:1958 → 2325
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01271
    Location:935 → 1040
    Granin; Granin (chromogranin or secretogranin)
    pfam00520
    Location:1484 → 1733
    Ion_trans; Ion transport protein
    pfam08763
    Location:1807 → 1881
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:1742 → 1795
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  11. XM_006497630.3 → XP_006497693.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X7

    UniProtKB/TrEMBL
    A2AIR7
    Conserved Domains (5) summary
    PHA03307
    Location:1953 → 2320
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01271
    Location:936 → 1041
    Granin; Granin (chromogranin or secretogranin)
    pfam00520
    Location:1481 → 1728
    Ion_trans; Ion transport protein
    pfam08763
    Location:1802 → 1876
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:1737 → 1790
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  12. XM_006497628.3 → XP_006497691.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X5

    UniProtKB/TrEMBL
    A2AIR7
    Conserved Domains (5) summary
    PHA03307
    Location:1955 → 2322
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01271
    Location:936 → 1041
    Granin; Granin (chromogranin or secretogranin)
    pfam00520
    Location:1481 → 1730
    Ion_trans; Ion transport protein
    pfam08763
    Location:1804 → 1878
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:1739 → 1792
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  13. XM_017315141.1 → XP_017170630.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X4

    UniProtKB/TrEMBL
    A2AIR7
    Conserved Domains (5) summary
    PHA03307
    Location:1957 → 2324
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01271
    Location:936 → 1041
    Granin; Granin (chromogranin or secretogranin)
    pfam00520
    Location:1485 → 1732
    Ion_trans; Ion transport protein
    pfam08763
    Location:1806 → 1880
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:1741 → 1794
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  14. XM_006497626.3 → XP_006497689.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X1

    UniProtKB/TrEMBL
    A2AIR7
    Conserved Domains (5) summary
    PHA03307
    Location:1959 → 2326
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01271
    Location:936 → 1041
    Granin; Granin (chromogranin or secretogranin)
    pfam00520
    Location:1485 → 1734
    Ion_trans; Ion transport protein
    pfam08763
    Location:1808 → 1882
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:1743 → 1796
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  15. XM_011239014.2 → XP_011237316.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X17

    UniProtKB/TrEMBL
    Q3UYN6
    Conserved Domains (4) summary
    PHA03307
    Location:850 → 1217
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam00520
    Location:376 → 625
    Ion_trans; Ion transport protein
    pfam08763
    Location:699 → 773
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:634 → 687
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  16. XM_006497637.5 → XP_006497700.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X14

    Conserved Domains (3) summary
    pfam01271
    Location:936 → 1041
    Granin; Granin (chromogranin or secretogranin)
    pfam00520
    Location:1485 → 1734
    Ion_trans; Ion transport protein
    pfam16905
    Location:1743 → 1756
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  17. XM_017315155.2 → XP_017170644.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X16

    Conserved Domains (3) summary
    pfam01271
    Location:936 → 1041
    Granin; Granin (chromogranin or secretogranin)
    pfam00520
    Location:1481 → 1728
    Ion_trans; Ion transport protein
    pfam16905
    Location:1737 → 1782
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  18. XM_006497638.4 → XP_006497701.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X15

    Conserved Domains (3) summary
    pfam01271
    Location:936 → 1041
    Granin; Granin (chromogranin or secretogranin)
    pfam00520
    Location:1485 → 1734
    Ion_trans; Ion transport protein
    pfam16905
    Location:1743 → 1788
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

RNA

  1. XR_003950091.2 RNA Sequence

  2. XR_374052.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O55017.1 GenPept UniProtKB/Swiss-Prot:O55017

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