Bmp8b bone morphogenetic protein 8b [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bmp8bprovided by MGI
Official Full Name: bone morphogenetic protein 8bprovided by MGI
Primary source: MGI:MGI:107335
See related: Ensembl:ENSMUSG00000002384 AllianceGenome:MGI:107335
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Op3
Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The encoded protein may play a role in the generation of primordial germ cells, and has been shown to stimulate thermogenesis in brown adipose tissue. Male mice lacking a functional copy of this gene exhibit variable degrees of germ-cell deficiency. Homozygous knockout mice of both sexes exhibit impaired thermogenesis and reduced metabolic rate, resulting in weight gain. This gene may have arose from a gene duplication event and its gene duplicate is also present on chromosome 4. [provided by RefSeq, Jul 2016]
Expression: Biased expression in small intestine adult (RPKM 3.9), large intestine adult (RPKM 1.9) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.2; 4 57.38 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (122998101..123019887)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (123104308..123126094)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BMP8B Activates Both SMAD2/3 and NF-kappaB Signals to Inhibit the Differentiation of 3T3-L1 Preadipocytes into Mature Adipocytes.
Title: BMP8B Activates Both SMAD2/3 and NF-κB Signals to Inhibit the Differentiation of 3T3-L1 Preadipocytes into Mature Adipocytes.
Obesity induces resistance to central action of BMP8B through a mechanism involving the BBSome.
Title: Obesity induces resistance to central action of BMP8B through a mechanism involving the BBSome.
Bone morphogenetic protein 8B promotes the progression of non-alcoholic steatohepatitis.
Title: Bone morphogenetic protein 8B promotes the progression of non-alcoholic steatohepatitis.
BMP8b and NRG4 can be considered as interconnected regulators of neuro-vascular remodeling in adipose tissue and are potential therapeutic targets in obesity.
Title: Adipocyte-secreted BMP8b mediates adrenergic-induced remodeling of the neuro-vascular network in adipose tissue.
Results indicate that BMP8B is a thermogenic protein that regulates energy balance in partnership with hypothalamic AMPK.
Title: BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

General gene information

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Markers

Bmp8b (e-PCR), detects polymorphism
- UniSTS:496646

PMC316497P2 (e-PCR)
- UniSTS:272996

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	TAS Traceable Author Statement more info	PubMed
enables growth factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cartilage development	IEA Inferred from Electronic Annotation more info
involved_in diet induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in energy homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ossification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: bone morphogenetic protein 8B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007559.5 → NP_031585.2 bone morphogenetic protein 8B preproprotein

See identical proteins and their annotated locations for NP_031585.2

Status: REVIEWED

Source sequence(s)

AK082895, AL606934, BQ031736, BQ551035

Consensus CDS

CCDS18608.1

UniProtKB/Swiss-Prot

P55105, Q8BNM2

Related

ENSMUSP00000002457.2, ENSMUST00000002457.2

Conserved Domains (2) summary

pfam00019
Location:298 → 398

TGF_beta; Transforming growth factor beta like domain

pfam00688
Location:32 → 248

TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

122998101..123019887

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011240420.2 → XP_011238722.1 bone morphogenetic protein 8B isoform X1

Conserved Domains (3) summary

pfam00688
Location:47 → 228

TGFb_propeptide; TGF-beta propeptide

pfam15180
Location:2 → 52

NPBW; Neuropeptides B and W

cl40434
Location:275 → 379

TGF_beta_SF; transforming growth factor beta (TGF-beta) like domain found in TGF-beta superfamily