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LYZL2 lysozyme like 2 [ Homo sapiens (human) ]

Gene ID: 119180, updated on 27-Nov-2024

Summary

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Official Symbol
LYZL2provided by HGNC
Official Full Name
lysozyme like 2provided by HGNC
Primary source
HGNC:HGNC:29613
See related
Ensembl:ENSG00000151033 MIM:612748; AllianceGenome:HGNC:29613
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LYZD2
Summary
Lysozymes (see LYZ; MIM 153450), especially C-type lysozymes, are well-recognized bacteriolytic factors widely distributed in the animal kingdom and play a mainly protective role in host defense. LYZL2 is a member of a family of lysozyme-like genes (Zhang et al., 2005 [PubMed 16014814]).[supplied by OMIM, Apr 2009]
Expression
Restricted expression toward testis (RPKM 14.7) See more
Orthologs
all
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Genomic context

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See LYZL2 in Genome Data Viewer
Location:
10p11.23
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (30606221..30629753, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (30637235..30660773, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (30900708..30918682, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:30847997-30848576 Neighboring gene RNA, 7SL, cytoplasmic 63, pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr10:30862856-30863438 Neighboring gene uncharacterized LOC105376479 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:30885919-30886534 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:30886535-30887149 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:30894172-30894987 Neighboring gene uncharacterized LOC124902404 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:30932862-30933433 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:30950154-30951353 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:30970851-30972050 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:30972911-30973410 Neighboring gene NANOG hESC enhancer GRCh37_chr10:30976431-30976969 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:30984558-30985757 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3221 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3222 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3223 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:30994171-30994694 Neighboring gene supervillin family member 2, pseudogene Neighboring gene long intergenic non-protein coding RNA 2644

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Molecular cloning and characterization of three novel lysozyme-like genes, predominantly expressed in the male reproductive system of humans, belonging to the c-type lysozyme/alpha-lactalbumin family. Zhang K, et al. Biol Reprod, 2005 Nov. PMID 16014814
  2. KIF5B gene sequence variation and response of cardiac stroke volume to regular exercise. Argyropoulos G, et al. Physiol Genomics, 2009 Jan 8. PMID 18984674, Free PMC Article
  3. GWAS of dental caries patterns in the permanent dentition. Shaffer JR, et al. J Dent Res, 2013 Jan. PMID 23064961, Free PMC Article
  4. The DNA sequence and comparative analysis of human chromosome 10. Deloukas P, et al. Nature, 2004 May 27. PMID 15164054
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Lamesch P, et al. Genomics, 2007 Mar. PMID 17207965, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
GWAS of dental caries patterns in the permanent dentition.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables lysozyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lysozyme-like protein 2
Names
lysozyme D2
lysozyme-2
NP_898881.3
XP_011517608.1
XP_011517609.1
XP_054220717.1
XP_054220718.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_183058.3 → NP_898881.3  lysozyme-like protein 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AF139543, AI637906, AL451107, BC066294
    Consensus CDS
    CCDS7167.3
    UniProtKB/Swiss-Prot
    Q6NZ69, Q7Z4W2
    Related
    ENSP00000497408.1, ENST00000647634.2
    Conserved Domains (1) summary
    cd00119
    Location:20 → 143
    LYZ1; C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    30606221..30629753 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011519306.3 → XP_011517608.1  lysozyme-like protein 2 isoform X1

    Related
    ENSP00000364467.2, ENST00000375318.4
    Conserved Domains (1) summary
    cl00222
    Location:66 → 145
    lysozyme_like; lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases. ...

  2. XM_011519307.3 → XP_011517609.1  lysozyme-like protein 2 isoform X2

    Conserved Domains (1) summary
    cl00222
    Location:66 → 146
    lysozyme_like; lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases. ...

RNA

  1. XR_930469.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    30637235..30660773 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054364742.1 → XP_054220717.1  lysozyme-like protein 2 isoform X1

  2. XM_054364743.1 → XP_054220718.1  lysozyme-like protein 2 isoform X2

RNA

  1. XR_008488166.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001031736.1: Suppressed sequence

    Description
    NM_001031736.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7Z4W2.2 GenPept UniProtKB/Swiss-Prot:Q7Z4W2

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