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Wipf1 WAS/WASL interacting protein family, member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 117538, updated on 27-Nov-2024

Summary

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Symbol
Wipf1provided by RGD
Full Name
WAS/WASL interacting protein family, member 1provided by RGD
Primary source
RGD:620887
See related
EnsemblRapid:ENSRNOG00000018406 AllianceGenome:RGD:620887
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Wip; Waspip
Summary
Predicted to enable SH3 domain binding activity and protein folding chaperone. Involved in actin cytoskeleton organization and positive regulation of protein export from nucleus. Located in actin filament. Orthologous to human WIPF1 (WAS/WASL interacting protein family member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 247.7), Thymus (RPKM 181.1) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Wipf1 in Genome Data Viewer
Location:
3q23
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (78721486..78824199, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (58314521..58416668, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (60150001..60207125, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 155 Neighboring gene uncharacterized LOC134486289 Neighboring gene uncharacterized LOC134486113 Neighboring gene uncharacterized LOC134486112 Neighboring gene uncharacterized LOC108350398 Neighboring gene ring-box 1, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Multiple WASP-interacting protein recognition motifs are required for a functional interaction with N-WASP. Peterson FC, et al. J Biol Chem, 2007 Mar 16. PMID 17229736
  2. The rat homologue of Wiskott-Aldrich syndrome protein (WASP)-interacting protein (WIP) associates with actin filaments, recruits N-WASP from the nucleus, and mediates mobilization of actin from stress fibers in favor of filopodia formation. Vetterkind S, et al. J Biol Chem, 2002 Jan 4. PMID 11687573
  3. Structure of the N-WASP EVH1 domain-WIP complex: insight into the molecular basis of Wiskott-Aldrich Syndrome. Volkman BF, et al. Cell, 2002 Nov 15. PMID 12437929
  4. Enteropathogenic Escherichia coli and vaccinia virus do not require the family of WASP-interacting proteins for pathogen-induced actin assembly. Garber JJ, et al. Infect Immun, 2012 Dec. PMID 22966049, Free PMC Article
  5. SPIN90/WISH interacts with PSD-95 and regulates dendritic spinogenesis via an N-WASP-independent mechanism. Lee S, et al. EMBO J, 2006 Oct 18. PMID 16990791, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. WASP-interacting protein recognition motifs are required for a functional interaction with N-WASP
    Title: Multiple WASP-interacting protein recognition motifs are required for a functional interaction with N-WASP.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
  
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein folding chaperone ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in actin filament-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament-based movement IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within actin filament-based movement ISO
Inferred from Sequence Orthology
more info
  
involved_in actin filament-based process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of protein export from nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
involved_in response to other organism IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to other organism ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in actin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actin filament IDA
Inferred from Direct Assay
more info
 PubMed 
located_in actin filament IEA
Inferred from Electronic Annotation
more info
  
located_in actin filament ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in ruffle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
WAS/WASL-interacting protein family member 1
Names
WASP-interacting protein
Wiskott-Aldrich syndrome protein interacting protein
translation initiation factor IF-2-like
wiskott-Aldrich syndrome protein-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429723.1 → NP_001416652.1  WAS/WASL-interacting protein family member 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6HM96, R9PXW1

  2. NM_001429724.1 → NP_001416653.1  WAS/WASL-interacting protein family member 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6HM96, R9PXW1

  3. NM_001429725.1 → NP_001416654.1  WAS/WASL-interacting protein family member 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6HM96, R9PXW1

  4. NM_001429726.1 → NP_001416655.1  WAS/WASL-interacting protein family member 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6HM96, R9PXW1

  5. NM_057192.2 → NP_476540.2  WAS/WASL-interacting protein family member 1

    See identical proteins and their annotated locations for NP_476540.2

    Status: PROVISIONAL

    Source sequence(s)
    BC072475
    UniProtKB/Swiss-Prot
    Q6IN36, Q8VDA4
    UniProtKB/TrEMBL
    A6HM96, R9PXW1
    Related
    ENSRNOP00000024922.6, ENSRNOT00000024922.8
    Conserved Domains (1) summary
    cd22076
    Location:29 → 60
    WH2_WAS_WASL-1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) in WAS/WASL-interacting protein family member 1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    78721486..78824199 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039104135.2 → XP_038960063.1  WAS/WASL-interacting protein family member 1 isoform X1

    Conserved Domains (1) summary
    cd22076
    Location:29 → 60
    WH2_WAS_WASL-1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) in WAS/WASL-interacting protein family member 1

  2. XM_039104136.2 → XP_038960064.1  WAS/WASL-interacting protein family member 1 isoform X1

    Conserved Domains (1) summary
    cd22076
    Location:29 → 60
    WH2_WAS_WASL-1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) in WAS/WASL-interacting protein family member 1

  3. XM_039104137.2 → XP_038960065.1  WAS/WASL-interacting protein family member 1 isoform X1

    Conserved Domains (1) summary
    cd22076
    Location:29 → 60
    WH2_WAS_WASL-1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) in WAS/WASL-interacting protein family member 1

  4. XM_039104138.2 → XP_038960066.1  WAS/WASL-interacting protein family member 1 isoform X1

    Conserved Domains (1) summary
    cd22076
    Location:29 → 60
    WH2_WAS_WASL-1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) in WAS/WASL-interacting protein family member 1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6IN36.2 GenPept UniProtKB/Swiss-Prot:Q6IN36

Gene LinkOut

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