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Scaper S-phase cyclin A-associated protein in the ER [ Rattus norvegicus (Norway rat) ]

Gene ID: 117521, updated on 27-Nov-2024

Summary

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Official Symbol
Scaperprovided by RGD
Official Full Name
S-phase cyclin A-associated protein in the ERprovided by RGD
Primary source
RGD:621585
See related
EnsemblRapid:ENSRNOG00000006864 AllianceGenome:RGD:621585
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Zfp291; Znf291
Summary
Predicted to enable nucleic acid binding activity and zinc ion binding activity. Predicted to act upstream of or within gonad development; retina development in camera-type eye; and spermatogenesis. Predicted to be located in several cellular components, including nuclear speck; ooplasm; and sperm head. Orthologous to human SCAPER (S-phase cyclin A associated protein in the ER). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 109.4), Heart (RPKM 86.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Scaper in Genome Data Viewer
Location:
8q24
Exon count:
39
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (64828789..65228240, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (55932717..56332222, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (60127039..60593568, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene bolA family member 2, pseudogene 1 Neighboring gene ISL LIM homeobox 2 Neighboring gene RNA-binding protein EWS-like Neighboring gene caspase-3-like Neighboring gene ubiquitin-conjugating enzyme E2 J2-like Neighboring gene kinesin-like protein KIF23 Neighboring gene sodium/potassium-transporting ATPase subunit beta-3-like Neighboring gene similar to PGC7 Neighboring gene developmental pluripotency associated 3-like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1454

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within antral ovarian follicle growth ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ovarian follicle development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within retina development in camera-type eye ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within seminiferous tubule development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in ooplasm ISO
Inferred from Sequence Orthology
more info
  
located_in sperm head ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
S phase cyclin A-associated protein in the endoplasmic reticulum
Names
KIAA1454-like protein
zinc finger protein 291

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427719.1 → NP_001414648.1  S phase cyclin A-associated protein in the endoplasmic reticulum

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    Related
    ENSRNOP00000110812.1, ENSRNOT00000171938.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    64828789..65228240 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008766363.4 → XP_008764585.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform X2

    See identical proteins and their annotated locations for XP_008764585.1

    UniProtKB/TrEMBL
    A6J4P9, F1LRM0
    Conserved Domains (6) summary
    smart00451
    Location:793 → 825
    ZnF_U1; U1-like zinc finger
    pfam09731
    Location:336 → 703
    Mitofilin; Mitochondrial inner membrane protein
    pfam16501
    Location:88 → 183
    SCAPER_N; S phase cyclin A-associated protein in the endoplasmic reticulum
    cd16269
    Location:763 → 773
    GBP_C; coiled coil [structural motif]
    cl02488
    Location:540 → 711
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl20817
    Location:669 → 777
    GBP_C; Guanylate-binding protein, C-terminal domain

  2. XM_039082386.2 → XP_038938314.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform X3

    UniProtKB/TrEMBL
    A6J4P9
    Conserved Domains (2) summary
    PTZ00121
    Location:532 → 918
    PTZ00121; MAEBL; Provisional
    pfam16501
    Location:94 → 191
    SCAPER_N; S phase cyclin A-associated protein in the endoplasmic reticulum

  3. XM_039082383.2 → XP_038938311.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform X1

    UniProtKB/TrEMBL
    A6J4P9
    Conserved Domains (2) summary
    PTZ00121
    Location:538 → 924
    PTZ00121; MAEBL; Provisional
    pfam16501
    Location:94 → 191
    SCAPER_N; S phase cyclin A-associated protein in the endoplasmic reticulum

  4. XM_039082384.2 → XP_038938312.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform X1

    UniProtKB/TrEMBL
    A6J4P9
    Conserved Domains (2) summary
    PTZ00121
    Location:538 → 924
    PTZ00121; MAEBL; Provisional
    pfam16501
    Location:94 → 191
    SCAPER_N; S phase cyclin A-associated protein in the endoplasmic reticulum

  5. XM_063264794.1 → XP_063120864.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform X2

    UniProtKB/TrEMBL
    F1LRM0

  6. XM_063264793.1 → XP_063120863.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform X1

  7. XM_039082388.2 → XP_038938316.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform X6

  8. XM_039082391.2 → XP_038938319.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform X8

  9. XM_063264796.1 → XP_063120866.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform X7

  10. XM_039082387.2 → XP_038938315.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform X4

    Conserved Domains (2) summary
    PTZ00121
    Location:538 → 924
    PTZ00121; MAEBL; Provisional
    pfam16501
    Location:94 → 191
    SCAPER_N; S phase cyclin A-associated protein in the endoplasmic reticulum

  11. XM_063264795.1 → XP_063120865.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform X5

Nucleotide Protein Strain
Heading Accession and Version

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