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RacGAP84C Rac GTPase activating protein at 84C [ Drosophila melanogaster (fruit fly) ]

Gene ID: 117503, updated on 4-Jan-2025

Summary

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Official Symbol
RacGAP84Cprovided by FlyBase
Official Full Name
Rac GTPase activating protein at 84Cprovided by FlyBase
Primary source
FLYBASE:FBgn0045843
Locus tag
Dmel_CG2595
See related
AllianceGenome:FB:FBgn0045843
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2595; Dmel\CG2595; GAP84C; P1.7; racGAP; RacGAP(84C); RhoGAP-84C8; rnGAP; rnprot; rnprot1.7; rnRac-GAP; rnracGap; rnracGAP; rnRacGap; rnRacGAP
Summary
Enables GTPase activator activity and small GTPase binding activity. Involved in Rho protein signal transduction; compound eye morphogenesis; and spermatogenesis. Predicted to be part of centralspindlin complex. Predicted to be active in several cellular components, including cleavage furrow; midbody; and spindle midzone. Is expressed in leg; ovary; spermatocyte; and testis. Human ortholog(s) of this gene implicated in congenital dyserythropoietic anemia. Orthologous to human RACGAP1 (Rac GTPase activating protein 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See RacGAP84C in Genome Data Viewer
Location:
84D3-84D3; 3-48 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7285962..7287629)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3111684..3113351)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene rotund Neighboring gene long non-coding RNA:CR44333 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44334

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A Drosophila rotund transcript expressed during spermatogenesis and imaginal disc morphogenesis encodes a protein which is similar to human Rac GTPase-activating (racGAP) proteins. Agnel M, et al. Mol Cell Biol, 1992 Nov. PMID 1406685, Free PMC Article
  2. Alternative splicing of the Drosophila melanogaster rotundRacGAP gene. Hoemann CD, et al. Gene, 1996 Feb 12. PMID 8654933
  3. Overexpression of RnRacGAP in Drosophila melanogaster deregulates cytoskeletal organisation in cellularising embryos and induces discrete imaginal phenotypes. Guichard A, et al. Mech Dev, 1997 Jan. PMID 9076677
  4. RotundRacGAP functions with Ras during spermatogenesis and retinal differentiation in Drosophila melanogaster. Bergeret E, et al. Mol Cell Biol, 2001 Sep. PMID 11509670, Free PMC Article
  5. Two transcripts from the rotund region of Drosophila show similar positional specificities in imaginal disc tissues. Agnel M, et al. Genes Dev, 1989 Jan. PMID 2496007

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Rho protein signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in compound eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle midzone assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of centralspindlin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cleavage furrow IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in midbody IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Rac GTPase activating protein at 84C
Names
CG2595-PA
CG2595-PB
RacGAP84C-PA
RacGAP84C-PB
RnRacGAP
RotundRACGAP
rotund RacGAP

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    7285962..7287629
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057356.5 → NP_476704.1  Rac GTPase activating protein at 84C, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476704.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P40809, Q9VI91
    Related
    FBpp0081099
    Conserved Domains (2) summary
    cd04382
    Location:142 → 330
    RhoGAP_MgcRacGAP; RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin ...
    pfam00130
    Location:87 → 139
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  2. NM_057355.4 → NP_476703.1  Rac GTPase activating protein at 84C, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476703.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P40809
    Related
    FBpp0081100
    Conserved Domains (2) summary
    cd04382
    Location:142 → 330
    RhoGAP_MgcRacGAP; RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin ...
    pfam00130
    Location:87 → 139
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40809.1 P40809

Gene LinkOut

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