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Gr64a Gustatory receptor 64a [ Drosophila melanogaster (fruit fly) ]

Gene ID: 117481, updated on 9-Dec-2024

Summary

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Official Symbol
Gr64aprovided by FlyBase
Official Full Name
Gustatory receptor 64aprovided by FlyBase
Primary source
FLYBASE:FBgn0045479
Locus tag
Dmel_CG32261
See related
AllianceGenome:FB:FBgn0045479
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14986; CG32261; Dmel64a; Dmel\CG32261; Gr64; GR64a; Gr64A1; GRLU.3; GrLU3; LU.3
Summary
Enables ionotropic sweet taste receptor activity and sweet taste receptor activity. Involved in detection of chemical stimulus involved in sensory perception of taste; proboscis extension reflex; and sensory perception of sweet taste. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adult brain; labral sense organ neurons; organism subdivision; posterior superior lateral protocerebrum; and wing disc. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Gr64a in Genome Data Viewer
Location:
64A4-64A4; 3-10 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4026769..4028600)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4026769..4028600)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Forkhead box L1 Neighboring gene Mitochondrial E3 ubiquitin protein ligase 1 Neighboring gene uncharacterized protein Neighboring gene Gustatory receptor 64c Neighboring gene Gustatory receptor 64b Neighboring gene Gustatory receptor 64d Neighboring gene Gustatory receptor 64e Neighboring gene antisense RNA:CR45042

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Starvation-induced elevation of taste responsiveness and expression of a sugar taste receptor gene in Drosophila melanogaster. Nishimura A, et al. J Neurogenet, 2012 Jun. PMID 22794108
  2. Structural basis for sugar perception by Drosophila gustatory receptors. Ma D, et al. Science, 2024 Feb 23. PMID 38305684
  3. Enterococci Mediate the Oviposition Preference of Drosophila melanogaster through Sucrose Catabolism. Liu W, et al. Sci Rep, 2017 Oct 18. PMID 29044155, Free PMC Article
  4. Secondary taste neurons that convey sweet taste and starvation in the Drosophila brain. Kain P, et al. Neuron, 2015 Feb 18. PMID 25661186
  5. Taste-independent detection of the caloric content of sugar in Drosophila. Dus M, et al. Proc Natl Acad Sci U S A, 2011 Jul 12. PMID 21709242, Free PMC Article

See all (100) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Here we sought to decipher the genes required for fructose response among Gr64a-Gr64f genes. Unexpectedly, the qPCR analyses for these genes show that labellar expression levels of Gr64d and Gr64e are higher in fructose low-sensitivity flies than in high-sensitivity flies
    Title: Deciphering the Genes for Taste Receptors for Fructose in Drosophila.
  2. The results of this study showed that the starvation-induced functional change in the taste sensory system and expression of a sugar taste receptor expression.
    Title: Starvation-induced elevation of taste responsiveness and expression of a sugar taste receptor gene in Drosophila melanogaster.
  3. Gr5a and Gr64a are each capable of functioning independently of each other within individual sugar neurons and that they are the primary receptors used in the labellum to detect sugars.(Gr64a protein, Drosophila)
    Title: Two Gr genes underlie sugar reception in Drosophila.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ionotropic sweet taste receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ligand-gated monoatomic ion channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables sweet taste receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sweet taste receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables taste receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables taste receptor activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in detection of chemical stimulus involved in sensory perception of taste IEA
Inferred from Electronic Annotation
more info
  
involved_in detection of chemical stimulus involved in sensory perception of taste IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in monoatomic ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proboscis extension reflex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sensory perception of sweet taste IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sensory perception of sweet taste IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in sensory perception of sweet taste IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sensory perception of taste NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
gustatory receptor 64a
Names
CG32261-PA
Gr64a-PA
gustatory receptor LU.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    4026769..4028600
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168048.2 → NP_728920.1  gustatory receptor 64a [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728920.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P83293, Q9VZJ7
    Related
    FBpp0073050
    Conserved Domains (1) summary
    pfam06151
    Location:48 → 452
    Trehalose_recp; Trehalose receptor
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P83293.1 P83293

Gene LinkOut

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