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Tsp68C Tetraspanin 68C [ Drosophila melanogaster (fruit fly) ]

Gene ID: 117407, updated on 9-Dec-2024

Summary

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Official Symbol
Tsp68Cprovided by FlyBase
Official Full Name
Tetraspanin 68Cprovided by FlyBase
Primary source
FLYBASE:FBgn0043550
Locus tag
Dmel_CG32136
See related
AllianceGenome:FB:FBgn0043550
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG32136; Dm.Tsp68C; Dmel\CG32136; Tsp68c
Summary
Involved in hemopoiesis. Located in perinuclear region of cytoplasm and trans-Golgi network. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Tsp68C in Genome Data Viewer
Location:
70C4-70C4; 3-41 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (13843656..13845316)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (13836756..13838416)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR46266 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Hemolectin Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Increased expression of Drosophila tetraspanin, Tsp68C, suppresses the abnormal proliferation of ytr-deficient and Ras/Raf-activated hemocytes. Sinenko SA, et al. Oncogene, 2004 Dec 2. PMID 15480416
  2. Genetic identification of intracellular trafficking regulators involved in Notch-dependent binary cell fate acquisition following asymmetric cell division. Le Bras S, et al. J Cell Sci, 2012 Oct 15. PMID 22825875
  3. Involvement of CD9 and PDGFR in migration is evolutionarily conserved from Drosophila glia to human glioma. Jeibmann A, et al. J Neurooncol, 2015 Sep. PMID 26224160
  4. The tetraspanin superfamily in insects. Todres E, et al. Insect Mol Biol, 2000 Dec. PMID 11122467
  5. Changes in organelle position and epithelial architecture associated with loss of CrebA. Fox RM, et al. Biol Open, 2015 Feb 13. PMID 25681391, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in hemopoiesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tetraspanin 68C
Names
CG32136-PA
CG32136-PC
Tetraspanin68C
Tsp68C-PA
Tsp68C-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    13843656..13845316
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168558.2 → NP_729926.1  tetraspanin 68C, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729926.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q4V3R4, Q8IQK8, Q8IQK9
    Related
    FBpp0075493
    Conserved Domains (2) summary
    cd03127
    Location:117 → 241
    tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
    pfam00335
    Location:8 → 267
    Tetraspannin; Tetraspanin family

  2. NM_168559.2 → NP_729927.2  tetraspanin 68C, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729927.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q4V3R4, Q8IQK8, Q8IQK9
    Conserved Domains (2) summary
    cd03127
    Location:117 → 241
    tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
    pfam00335
    Location:8 → 267
    Tetraspannin; Tetraspanin family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IQK9 Q8IQK9

Gene LinkOut

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