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Pcyt1 Phosphocholine cytidylyltransferase 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 117353, updated on 9-Dec-2024

Summary

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Official Symbol
Pcyt1provided by FlyBase
Official Full Name
Phosphocholine cytidylyltransferase 1provided by FlyBase
Primary source
FLYBASE:FBgn0041342
Locus tag
Dmel_CG1049
See related
AllianceGenome:FB:FBgn0041342
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Cct; cct1; Cct1; CCT1; CG1049; CT41283; Dmel\CG1049; pcyt1
Summary
Enables choline-phosphate cytidylyltransferase activity. Involved in several processes, including determination of adult lifespan; establishment of ommatidial planar polarity; and imaginal disc-derived wing morphogenesis. Located in nucleus. Is expressed in several structures, including adult head; amnioserosa primordium; anterior endoderm; embryonic/larval midgut primordium; and epithelium. Human ortholog(s) of this gene implicated in congenital generalized lipodystrophy and spondylometaphyseal dysplasia with cone-rod dystrophy. Orthologous to human PCYT1A (phosphate cytidylyltransferase 1A, choline). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Pcyt1 in Genome Data Viewer
Location:
62A3-62A5; 3-0.5 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1546092..1553504)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1546092..1553504)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene pinstripe Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45813 Neighboring gene Phosphocholine cytidylyltransferase 2 Neighboring gene uncharacterized protein Neighboring gene Peroxin 10 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification and characterization of the nuclear isoform of Drosophila melanogaster CTP:phosphocholine cytidylyltransferase. Tilley DM, et al. Biochemistry, 2008 Nov 11. PMID 18922025
  2. Characterization of a lipid activated CTP:phosphocholine cytidylyltransferase from Drosophila melanogaster. Helmink BA, et al. Biochim Biophys Acta, 2004 Jul 5. PMID 15238222
  3. Membrane Asymmetry Imposes Directionality on Lipid Droplet Emergence from the ER. Chorlay A, et al. Dev Cell, 2019 Jul 1. PMID 31155466
  4. Phosphatidylcholine synthesis for lipid droplet expansion is mediated by localized activation of CTP:phosphocholine cytidylyltransferase. Krahmer N, et al. Cell Metab, 2011 Oct 5. PMID 21982710, Free PMC Article
  5. Torsins Are Essential Regulators of Cellular Lipid Metabolism. Grillet M, et al. Dev Cell, 2016 Aug 8. PMID 27453503

See all (75) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CTP:phosphocholine cytidylyltransferase regulates phospholipid homeostatis druing lipid droplets expansion.
    Title: Phosphatidylcholine synthesis for lipid droplet expansion is mediated by localized activation of CTP:phosphocholine cytidylyltransferase.
  2. Proteomic analysis reveals Cct1 is a target of FMR1 protein regulation in Drosophila.
    Title: Proteomic analysis reveals CCT is a target of Fragile X mental retardation protein regulation in Drosophila.
  3. CCT1 was identified as the nuclear isoform.
    Title: Identification and characterization of the nuclear isoform of Drosophila melanogaster CTP:phosphocholine cytidylyltransferase.
  4. Data provide evidence for a specific role for CTP: phosphocholine cytidylyltransferase, and thus for phosphatidylcholine, in patterning during development.
    Title: Cct1, a phosphatidylcholine biosynthesis enzyme, is required for Drosophila oogenesis and ovarian morphogenesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables choline-phosphate cytidylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables choline-phosphate cytidylyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables choline-phosphate cytidylyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylcholine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in CDP-choline pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of ommatidial planar polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in eye development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in imaginal disc-derived wing morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidylcholine biosynthetic process IC
Inferred by Curator
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
phosphocholine cytidylyltransferase 1
Names
CG1049-PA
CG1049-PB
CG1049-PC
CG1049-PD
CG1049-PE
CG1049-PF
CTP-phosphocholine cytidylyltransferase
CTP:phosphocholine cytidylyltransferase
CTP:phosphocholine cytidylyltransferase 1
Pcyt1-PA
Pcyt1-PB
Pcyt1-PC
Pcyt1-PD
Pcyt1-PE
Pcyt1-PF
cytidylyltransferase 1
phosphocholine cytidylyltransferase
NP_001261264.1
NP_001286898.1
NP_647621.1
NP_728626.1
NP_728627.1
NP_728628.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    1546092..1553504
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299969.1 → NP_001286898.1  phosphocholine cytidylyltransferase 1, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286898.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K4C7
    Conserved Domains (2) summary
    cd02174
    Location:204 → 353
    CCT; CTP:phosphocholine cytidylyltransferase
    PLN02413
    Location:202 → 462
    PLN02413; choline-phosphate cytidylyltransferase

  2. NM_001274335.1 → NP_001261264.1  phosphocholine cytidylyltransferase 1, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261264.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K4C7
    Conserved Domains (2) summary
    cd02174
    Location:204 → 353
    CCT; CTP:phosphocholine cytidylyltransferase
    PLN02413
    Location:202 → 462
    PLN02413; choline-phosphate cytidylyltransferase

  3. NM_139364.3 → NP_647621.1  phosphocholine cytidylyltransferase 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647621.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K4C7
    Related
    FBpp0072621
    Conserved Domains (2) summary
    cd02174
    Location:204 → 353
    CCT; CTP:phosphocholine cytidylyltransferase
    PLN02413
    Location:202 → 462
    PLN02413; choline-phosphate cytidylyltransferase

  4. NM_167894.2 → NP_728628.1  phosphocholine cytidylyltransferase 1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728628.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K4C7
    Related
    FBpp0072622
    Conserved Domains (2) summary
    cd02174
    Location:204 → 353
    CCT; CTP:phosphocholine cytidylyltransferase
    PLN02413
    Location:202 → 462
    PLN02413; choline-phosphate cytidylyltransferase

  5. NM_167892.2 → NP_728626.1  phosphocholine cytidylyltransferase 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728626.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K4C7
    Related
    FBpp0072623
    Conserved Domains (2) summary
    cd02174
    Location:204 → 353
    CCT; CTP:phosphocholine cytidylyltransferase
    PLN02413
    Location:202 → 462
    PLN02413; choline-phosphate cytidylyltransferase

  6. NM_167893.2 → NP_728627.1  phosphocholine cytidylyltransferase 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728627.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K4C7
    Related
    FBpp0072624
    Conserved Domains (2) summary
    cd02174
    Location:204 → 353
    CCT; CTP:phosphocholine cytidylyltransferase
    PLN02413
    Location:202 → 462
    PLN02413; choline-phosphate cytidylyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7K4C7 Q7K4C7

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