Pdha2 pyruvate dehydrogenase E1 subunit alpha 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pdha2provided by RGD
Official Full Name: pyruvate dehydrogenase E1 subunit alpha 2provided by RGD
Primary source: RGD:620095
See related: EnsemblRapid:ENSRNOG00000077743 AllianceGenome:RGD:620095
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pdhal
Summary: Enables pyruvate dehydrogenase (acetyl-transferring) activity. Involved in acetyl-CoA biosynthetic process from pyruvate. Part of pyruvate dehydrogenase complex. Human ortholog(s) of this gene implicated in spermatogenic failure 70. Orthologous to human PDHA2 (pyruvate dehydrogenase E1 subunit alpha 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: 2q44

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (232545550..232547098, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (229872300..229873848, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (246736449..246737997, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables pyruvate dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables pyruvate dehydrogenase (acetyl-transferring) activity	IBA Inferred from Biological aspect of Ancestor more info
enables pyruvate dehydrogenase (acetyl-transferring) activity	IDA Inferred from Direct Assay more info	PubMed
enables pyruvate dehydrogenase (acetyl-transferring) activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in acetyl-CoA biosynthetic process from pyruvate	IBA Inferred from Biological aspect of Ancestor more info
involved_in acetyl-CoA biosynthetic process from pyruvate	IDA Inferred from Direct Assay more info	PubMed
involved_in glucose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in pyruvate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in pyruvate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
part_of pyruvate dehydrogenase complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial

Names: PDHE1-A type II; pyruvate dehydrogenase (lipoamide) alpha 2; pyruvate dehydrogenase E1 alpha 2 subunit; pyruvate dehydrogenase alpha 2

NP_446446.1

EC 1.2.4.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053994.2 → NP_446446.1 pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial precursor

See identical proteins and their annotated locations for NP_446446.1

Status: VALIDATED

Source sequence(s)

BC078757

UniProtKB/Swiss-Prot

Q06437

UniProtKB/TrEMBL

A6HW52

Related

ENSRNOP00000099911.1, ENSRNOT00000166183.1

Conserved Domains (1) summary

TIGR03182
Location:59 → 371

PDH_E1_alph_y; pyruvate dehydrogenase E1 component, alpha subunit