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Adarb2 adenosine deaminase RNA specific B2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 117088, updated on 4-Jan-2025

Summary

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Official Symbol
Adarb2provided by RGD
Official Full Name
adenosine deaminase RNA specific B2provided by RGD
Primary source
RGD:621519
See related
EnsemblRapid:ENSRNOG00000030775 AllianceGenome:RGD:621519
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Red2; Adar3
Summary
Predicted to enable double-stranded RNA adenosine deaminase activity; double-stranded RNA binding activity; and tRNA-specific adenosine deaminase activity. Predicted to be involved in RNA processing and adenosine to inosine editing. Predicted to be located in nucleus. Predicted to be active in cytoplasm and nucleolus. Orthologous to human ADARB2 (adenosine deaminase RNA specific B2 (inactive)). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Restricted expression toward (RPKM 61.9) See more
Orthologs
human mouse all
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Genomic context

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See Adarb2 in Genome Data Viewer
Location:
17q12.1
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (66660586..67211104, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (61750437..62300984, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (58098979..58653137, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482867 Neighboring gene WD repeat domain 37 Neighboring gene isopentenyl-diphosphate delta isomerase 1 Neighboring gene uncharacterized LOC134482734 Neighboring gene uncharacterized LOC102552293 Neighboring gene elongin B like 1 Neighboring gene uncharacterized LOC134482780 Neighboring gene uncharacterized LOC134482781

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. RED2, a brain-specific member of the RNA-specific adenosine deaminase family. Melcher T, et al. J Biol Chem, 1996 Dec 13. PMID 8943218
  2. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables adenosine deaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded RNA adenosine deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables tRNA-specific adenosine deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in RNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in adenosine to inosine editing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
double-stranded RNA-specific editase B2
Names
RNA-dependent adenosine deaminase 3
RNA-editing deaminase 2
RNA-editing enzyme 2
adenosine deaminase 3, RNA dependent
dsRNA adenosine deaminase B2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133302.2 → NP_579836.1  double-stranded RNA-specific editase B2

    See identical proteins and their annotated locations for NP_579836.1

    Status: PROVISIONAL

    Source sequence(s)
    U74586
    UniProtKB/Swiss-Prot
    P97616
    UniProtKB/TrEMBL
    A6KRP0, F1LSW5
    Related
    ENSRNOP00000047468.6, ENSRNOT00000047512.6
    Conserved Domains (3) summary
    smart00358
    Location:285 → 332
    DSRM; Double-stranded RNA binding motif
    smart00552
    Location:367 → 743
    ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
    cd00048
    Location:126 → 190
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    66660586..67211104 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039095307.2 → XP_038951235.1  double-stranded RNA-specific editase B2 isoform X2

    UniProtKB/TrEMBL
    A6KRP0, F1LSW5
    Conserved Domains (3) summary
    cd19896
    Location:123 → 196
    DSRM_RED2_rpt1; first double-stranded RNA binding motif of RNA-editing deaminase 2 (RED2) and similar proteins
    cl00054
    Location:277 → 350
    DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily
    cl02661
    Location:367 → 636
    A_deamin; Adenosine-deaminase (editase) domain

  2. XM_017600442.3 → XP_017455931.2  double-stranded RNA-specific editase B2 isoform X1

    UniProtKB/TrEMBL
    A6KRP0, F1LSW5
    Related
    ENSRNOP00000110240.1, ENSRNOT00000157779.1
    Conserved Domains (3) summary
    smart00552
    Location:367 → 688
    ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
    cd19896
    Location:123 → 196
    DSRM_RED2_rpt1; first double-stranded RNA binding motif of RNA-editing deaminase 2 (RED2) and similar proteins
    cl00054
    Location:277 → 350
    DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97616.1 GenPept UniProtKB/Swiss-Prot:P97616

Gene LinkOut

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