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Calb2 calbindin 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 117059, updated on 27-Nov-2024

Summary

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Symbol
Calb2provided by RGD
Full Name
calbindin 2provided by RGD
Primary source
RGD:620981
See related
AllianceGenome:RGD:620981
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables calcium ion binding activity. Predicted to be involved in regulation of long-term synaptic potentiation and regulation of presynaptic cytosolic calcium ion concentration. Located in cuticular plate and stereocilium. Is active in synapse. Orthologous to human CALB2 (calbindin 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 382.5) and Testes (RPKM 140.9) See more
Orthologs
human mouse all
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Genomic context

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See Calb2 in Genome Data Viewer
Location:
19q12
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (55023849..55050858, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (38114435..38141438, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (41482743..41509617)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene TLE family member 7 Neighboring gene uncharacterized LOC102553877 Neighboring gene 40S ribosomal protein S18 pseudogene Neighboring gene uncharacterized LOC134483364

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Immunocytochemical detection of calretinin in the claustrum and endopiriform nucleus of the chinchilla. Szalak R, et al. Pol J Vet Sci, 2015. PMID 26812830
  2. Neonatal hypoxic/ischemic brain injury induces production of calretinin-expressing interneurons in the striatum. Yang Z, et al. J Comp Neurol, 2008 Nov 1. PMID 18720478, Free PMC Article
  3. Calretinin gene promoter activity is differently regulated in neurons and cancer cells. Role of AP2-like cis element and zinc ions. Billing-Marczak K, et al. Biochim Biophys Acta, 2004 Apr 16. PMID 15093134
  4. Neurogenesis and stereological morphometry of calretinin-immunoreactive GABAergic interneurons of the neostriatum. Rymar VV, et al. J Comp Neurol, 2004 Feb 9. PMID 14730585
  5. The Ca(2+)-binding protein calretinin is selectively enriched in a subpopulation of the epithelial rests of Malassez. Korkmaz Y, et al. Cell Tissue Res, 2010 Dec. PMID 21080000

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression of calbindin and calretinin in the dorsomedial and ventromedial hypothalamic nuclei during aging.
    Title: Expression of calbindin and calretinin in the dorsomedial and ventromedial hypothalamic nuclei during aging.
  2. Quantitative analysis of the transient changes in calretinin expression by hybridochemistry within neuronal cell populations in the hippocampus of a beta amyloid-treated rat model of Alzheimer's disease and their correlation with endocannabinoid increase
    Title: Analysis of calretinin early expression in the rat hippocampus after beta amyloid (1-42) peptide injection.
  3. A role for calreticulin in functioning of mitochondrial ATP-dependent potassium channel
    Title: [A role for calreticulin in functioning of mitochondrial ATP-dependent potassium channel].
  4. distribution of the cell-specific markers, calretinin and calbindin, in reelin-immunoreactive cells during postnatal rat and mouse neocortical development
    Title: Expression of calcium-binding proteins in layer 1 reelin-immunoreactive cells during rat and mouse neocortical development.
  5. The stress of maternal deprivation has a significant effect on calretinin and calbindin expression in both male and female ratss, but affects glucocorticoid receptor levels only in males.
    Title: The effect of different maternal deprivation paradigms on the expression of hippocampal glucocorticoid receptors, calretinin and calbindin-D28k in male and female adolescent rats.
  6. An essential property of calretinin action potentials is a delayed equilibration with divalent calcium ions.
    Title: Effects of calretinin on Ca2+ signals in cerebellar granule cells: implications of cooperative Ca2+ binding.
  7. Studied the general pattern of calretinin (CR), parvalbumin (PV) and calbindin (CB) immunoreactivity as well as morphological features and density of CR and PV immunoreactive (CR+, PV+) interneurons in the rat perirhinal cortex (PRC) and found the PRC possesses specific interneuronal equipment with unusually high proportion of CR+ interneurons.
    Title: Calretinin, parvalbumin and calbindin immunoreactive interneurons in perirhinal cortex and temporal area Te3V of the rat brain: qualitative and quantitative analyses.
  8. results suggest that hypothyroidism ameliorated the diabetes-induced reduction of CB, CR, and PV immunoreactivity in the hippocampus
    Title: Hypothyroid states mitigate the diabetes-induced reduction of calbindin D-28k, calretinin, and parvalbumin immunoreactivity in type 2 diabetic rats.
  9. study concludes that, in inner and outer enamel epithelial cells, Ca(2+)is regulated by calbindin, parvalbumin and calretinin during tooth development; in epithelial rests of Malassez of adult periodontal ligament, Ca(2+) is regulated only by calretinin
    Title: The Ca(2+)-binding protein calretinin is selectively enriched in a subpopulation of the epithelial rests of Malassez.
  10. There is a clear compartmentalization of calbindin-28 kDa and calretinin distribution in retinal ganglion cells.
    Title: Subcellular compartmentalization of two calcium binding proteins, calretinin and calbindin-28 kDa, in ganglion and amacrine cells of the rat retina.
Submit: New GeneRIF Correction See all GeneRIFs (18)

General gene information

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Markers

Homology

Clone Names

  • MGC105356

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in regulation of long-term synaptic potentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of presynaptic cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of presynaptic cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cuticular plate IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in gap junction IEA
Inferred from Electronic Annotation
more info
  
located_in gap junction ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in parallel fiber to Purkinje cell synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in parallel fiber to Purkinje cell synapse ISO
Inferred from Sequence Orthology
more info
  
located_in presynapse IEA
Inferred from Electronic Annotation
more info
  
located_in stereocilium IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in terminal bouton HDA PubMed 
is_active_in terminal bouton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in vestibular calyx terminal ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
calretinin
Names
CR

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053988.2 → NP_446440.1  calretinin

    See identical proteins and their annotated locations for NP_446440.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/Swiss-Prot
    P47728
    UniProtKB/TrEMBL
    A0A8I6ADK6, A6IZ54
    Conserved Domains (1) summary
    cd16177
    Location:21 → 268
    EFh_HEF_CR; EF-hand, calcium binding motif, found in calretinin (CR)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    55023849..55050858 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47728.1 GenPept UniProtKB/Swiss-Prot:P47728

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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