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Rps15a ribosomal protein S15a [ Rattus norvegicus (Norway rat) ]

Gene ID: 117053, updated on 27-Nov-2024

Summary

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Official Symbol
Rps15aprovided by RGD
Official Full Name
ribosomal protein S15aprovided by RGD
Primary source
RGD:619939
See related
EnsemblRapid:ENSRNOG00000018320 AllianceGenome:RGD:619939
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be a structural constituent of ribosome. Predicted to be involved in several processes, including positive regulation of cell population proliferation; response to virus; and ribosomal small subunit biogenesis. Part of cytosolic small ribosomal subunit. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 20. Orthologous to human RPS15A (ribosomal protein S15a). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 4437.8), Thymus (RPKM 3778.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rps15a in Genome Data Viewer
Location:
1q35
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (181854396..181861330, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (172420151..172427021, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (187759865..187766734, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485168 Neighboring gene uncharacterized LOC134485169 Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 109 Neighboring gene ARL6 interacting reticulophagy regulator 1 Neighboring gene SMG1, nonsense mediated mRNA decay associated PI3K related kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. RPS15A Mediates PI3K/AKT Signaling-Induced Parathyroid Cell Proliferation in Rats with Secondary Hyperparathyroidism. Chen R, et al. Ann Clin Lab Sci, 2023 Mar. PMID 37094854
  2. The primary structure of rat ribosomal protein S15a. Chan YL, et al. Biochem Biophys Res Commun, 1994 May 16. PMID 8185605
  3. Human S15a expression is upregulated by hepatitis B virus X protein. Lian Z, et al. Mol Carcinog, 2004 May. PMID 15108328
  4. Isolation of eukaryotic ribosomal proteins. Purification and characterization of the 40 S ribosomal subunit proteins Sa, Sc, S3a, S3b, S5', S9, S10, S11, S12, S14, S15, S15', S16, S17, S18, S19, S20, S21, S26, S27', and S29. Collatz E, et al. J Biol Chem, 1977 Dec 25. PMID 925037
  5. Functional dichotomy of ribosomal proteins during the synthesis of mammalian 40S ribosomal subunits. O'Donohue MF, et al. J Cell Biol, 2010 Sep 6. PMID 20819938, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RPS15A Mediates PI3K/AKT Signaling-Induced Parathyroid Cell Proliferation in Rats with Secondary Hyperparathyroidism.
    Title: RPS15A Mediates PI3K/AKT Signaling-Induced Parathyroid Cell Proliferation in Rats with Secondary Hyperparathyroidism.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of ribosome ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in positive regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosomal small subunit biogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosomal small subunit biogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
  
part_of cytosolic small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic small ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic small ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  
part_of small-subunit processome ISO
Inferred from Sequence Orthology
more info
  
part_of small-subunit processome ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
small ribosomal subunit protein uS8
Names
40S ribosomal protein S15a
NP_446434.1
XP_006230159.1
XP_006230160.1
XP_038968660.1
XP_038968702.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053982.1 → NP_446434.1  small ribosomal subunit protein uS8

    See identical proteins and their annotated locations for NP_446434.1

    Status: PROVISIONAL

    Source sequence(s)
    X77953
    UniProtKB/Swiss-Prot
    P62246
    UniProtKB/TrEMBL
    A0A0G2JYA6, A6I8G0
    Conserved Domains (1) summary
    PTZ00158
    Location:1 → 130
    PTZ00158; 40S ribosomal protein S15A; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    181854396..181861330 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006230097.3 → XP_006230159.1  small ribosomal subunit protein uS8 isoform X1

    See identical proteins and their annotated locations for XP_006230159.1

    UniProtKB/Swiss-Prot
    P62246
    UniProtKB/TrEMBL
    A0A0G2JYA6, A6I8G0
    Conserved Domains (1) summary
    PTZ00158
    Location:1 → 130
    PTZ00158; 40S ribosomal protein S15A; Provisional

  2. XM_006230098.4 → XP_006230160.1  small ribosomal subunit protein uS8 isoform X1

    See identical proteins and their annotated locations for XP_006230160.1

    UniProtKB/Swiss-Prot
    P62246
    UniProtKB/TrEMBL
    A0A0G2JYA6, A6I8G0
    Related
    ENSRNOP00000075747.3, ENSRNOT00000092513.3
    Conserved Domains (1) summary
    PTZ00158
    Location:1 → 130
    PTZ00158; 40S ribosomal protein S15A; Provisional

  3. XM_039112732.1 → XP_038968660.1  small ribosomal subunit protein uS8 isoform X1

    UniProtKB/Swiss-Prot
    P62246
    UniProtKB/TrEMBL
    A0A0G2JYA6, A6I8G0
    Conserved Domains (1) summary
    PTZ00158
    Location:1 → 130
    PTZ00158; 40S ribosomal protein S15A; Provisional

  4. XM_039112774.2 → XP_038968702.1  small ribosomal subunit protein uS8 isoform X1

    UniProtKB/Swiss-Prot
    P62246
    UniProtKB/TrEMBL
    A0A0G2JYA6, A6I8G0
    Conserved Domains (1) summary
    PTZ00158
    Location:1 → 130
    PTZ00158; 40S ribosomal protein S15A; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62246.2 GenPept UniProtKB/Swiss-Prot:P62246

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