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Cdh3 cadherin 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 116777, updated on 27-Nov-2024

Summary

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Official Symbol
Cdh3provided by RGD
Official Full Name
cadherin 3provided by RGD
Primary source
RGD:621089
See related
EnsemblRapid:ENSRNOG00000020129 AllianceGenome:RGD:621089
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable beta-catenin binding activity and cadherin binding activity. Involved in response to xenobiotic stimulus. Predicted to be located in cell junction and plasma membrane. Predicted to be part of catenin complex. Predicted to be active in adherens junction and cytoplasm. Human ortholog(s) of this gene implicated in congenital hypotrichosis with juvenile macular dystrophy and ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome. Orthologous to human CDH3 (cadherin 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 40.1), Kidney (RPKM 31.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cdh3 in Genome Data Viewer
Location:
19q12
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (51303414..51353900)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (34393596..34444084)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (38668957..38719801)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S12 like 1 Neighboring gene ribosomal protein L28 like 1 Neighboring gene cadherin 1 Neighboring gene transport and golgi organization 6 homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Changes in the expression of P-cadherin in the normal, cryptorchid and busulphan-treated rat testis. Pospechova K, et al. Int J Androl, 2007 Oct. PMID 17298545
  2. Topobiology of human pigmentation: P-cadherin selectively stimulates hair follicle melanogenesis. Samuelov L, et al. J Invest Dermatol, 2013 Jun. PMID 23334344
  3. Homozygous deletion in CDH3 and hypotrichosis with juvenile macular dystrophy. Halford S, et al. Arch Ophthalmol, 2012 Nov. PMID 23143461
  4. P-cadherin regulates human hair growth and cycling via canonical Wnt signaling and transforming growth factor-β2. Samuelov L, et al. J Invest Dermatol, 2012 Oct. PMID 22696062
  5. Expression of P-cadherin distinct from that of E-cadherin in re-epithelialization in neonatal rat skin. Koizumi M, et al. Dev Growth Differ, 2005 Feb. PMID 15771627

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Diabetic proteinuria is mediated by the activation of 12-LO pathway that is partially attributed to the decreased glomerular P-cadherin expression.
    Title: Role of 12-lipoxygenase in decreasing P-cadherin and increasing angiotensin II type 1 receptor expression according to glomerular size in type 2 diabetic rats.
  2. expressed throughout prepubertal ovarian development
    Title: Expression and localization of P-, K-, and OB-cadherin in the prepubertal rat ovary.
  3. Comparison of the expression patterns of E- and P-cadherins during wound healing of the epidermis strongly suggests that these two cadherins play distinct roles in re-epithelialization.
    Title: Expression of P-cadherin distinct from that of E-cadherin in re-epithelialization in neonatal rat skin.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables beta-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cadherin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in adherens junction organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in cell-cell adhesion mediated by cadherin IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hair cycle process ISO
Inferred from Sequence Orthology
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
  
involved_in keratinization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of timing of catagen ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within_negative_effect negative regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_positive_effect positive regulation of insulin-like growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of keratinocyte proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of melanin biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of melanosome transport ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of tyrosinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in retina homeostasis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
  
part_of catenin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cadherin-3
Names
cadherin 3, type 1, P-cadherin (placental)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053938.2 → NP_446390.2  cadherin-3 precursor

    See identical proteins and their annotated locations for NP_446390.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/TrEMBL
    A6IYX2, F1LMI3
    Related
    ENSRNOP00000027273.8, ENSRNOT00000027273.9
    Conserved Domains (3) summary
    cd11304
    Location:211 → 316
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam01049
    Location:680 → 817
    Cadherin_C; Cadherin cytoplasmic region
    cl09101
    Location:103 → 203
    E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    51303414..51353900
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006255559.5 → XP_006255621.1  cadherin-3 isoform X1

    Related
    ENSRNOP00000105187.1, ENSRNOT00000131260.1
    Conserved Domains (3) summary
    cd11304
    Location:207 → 312
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam01049
    Location:676 → 813
    Cadherin_C; Cadherin cytoplasmic region
    cl09101
    Location:99 → 199
    E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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