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Cgrrf1 cell growth regulator with ring finger domain 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 116679, updated on 4-Jan-2025

Summary

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Official Symbol
Cgrrf1provided by RGD
Official Full Name
cell growth regulator with ring finger domain 1provided by RGD
Primary source
RGD:620803
See related
EnsemblRapid:ENSRNOG00000010178 AllianceGenome:RGD:620803
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cgr19
Summary
Predicted to enable metal ion binding activity. Involved in negative regulation of cell growth. Predicted to be located in endoplasmic reticulum and nucleoplasm. Orthologous to human CGRRF1 (cell growth regulator with ring finger domain 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Muscle (RPKM 226.0), Liver (RPKM 149.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cgrrf1 in Genome Data Viewer
Location:
15p14
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (22560902..22588815)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (20088564..20109042)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (23619176..23639622)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene cornichon family member 1 Neighboring gene glia maturation factor, beta Neighboring gene ribosomal protein L39, pseudogene 11 Neighboring gene uncharacterized LOC102548367 Neighboring gene sterile alpha motif domain containing 4A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Induction of cell growth regulatory genes by p53. Madden SL, et al. Cancer Res, 1996 Dec 1. PMID 8968090
  2. Genome-wide identification and gene expression profiling of ubiquitin ligases for endoplasmic reticulum protein degradation. Kaneko M, et al. Sci Rep, 2016 Aug 3. PMID 27485036, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC93274

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of cell growth IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cell growth IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cell growth regulator with RING finger domain protein 1
Names
cell growth regulatory gene 19 protein
cell growth regulatory with ring finger domain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053899.2 → NP_446351.2  cell growth regulator with RING finger domain protein 1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/Swiss-Prot
    P97587
    UniProtKB/TrEMBL
    A6KE27, G3V7C9
    Related
    ENSRNOP00000013912.3, ENSRNOT00000013912.8
    Conserved Domains (1) summary
    cd16787
    Location:273 → 309
    mRING-HC-C3HC5_CGRF1; Modified RING finger, HC subclass (C3HC5-type), found in cell growth regulator with RING finger domain protein 1 (CGRRF1) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    22560902..22588815
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063273912.1 → XP_063129982.1  cell growth regulator with RING finger domain protein 1 isoform X2

    UniProtKB/Swiss-Prot
    P97587
    UniProtKB/TrEMBL
    A6KE27, G3V7C9

  2. XM_039092952.1 → XP_038948880.1  cell growth regulator with RING finger domain protein 1 isoform X1

    UniProtKB/Swiss-Prot
    P97587
    Related
    ENSRNOP00000102853.1, ENSRNOT00000152052.1
    Conserved Domains (1) summary
    cd16787
    Location:298 → 334
    mRING-HC-C3HC5_CGRF1; Modified RING finger, HC subclass (C3HC5-type), found in cell growth regulator with RING finger domain protein 1 (CGRRF1) and similar proteins

  3. XM_039092954.2 → XP_038948882.1  cell growth regulator with RING finger domain protein 1 isoform X4

    UniProtKB/TrEMBL
    A6KE30
    Conserved Domains (1) summary
    cd16787
    Location:204 → 240
    mRING-HC-C3HC5_CGRF1; Modified RING finger, HC subclass (C3HC5-type), found in cell growth regulator with RING finger domain protein 1 (CGRRF1) and similar proteins

  4. XM_039092953.2 → XP_038948881.1  cell growth regulator with RING finger domain protein 1 isoform X3

    Conserved Domains (1) summary
    cd16787
    Location:229 → 265
    mRING-HC-C3HC5_CGRF1; Modified RING finger, HC subclass (C3HC5-type), found in cell growth regulator with RING finger domain protein 1 (CGRRF1) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97587.1 GenPept UniProtKB/Swiss-Prot:P97587

Gene LinkOut

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