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Serpinb5 serpin family B member 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 116589, updated on 9-Dec-2024

Summary

Official Symbol
Serpinb5provided by RGD
Official Full Name
serpin family B member 5provided by RGD
Primary source
RGD:69342
See related
EnsemblRapid:ENSRNOG00000002640 AllianceGenome:RGD:69342
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pi5; PI-5; Maspin
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to act upstream of or within several processes, including extracellular matrix organization; prostate gland morphogenesis; and regulation of epithelial cell proliferation. Predicted to be located in sarcoplasm. Predicted to be active in cornified envelope and extracellular space. Orthologous to human SERPINB5 (serpin family B member 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Thymus (RPKM 84.1), Lung (RPKM 25.1) and 1 other tissue See more
Orthologs
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Genomic context

See Serpinb5 in Genome Data Viewer
Location:
13p11
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (23500203..23520401)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (22985557..23005756)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (26903052..26923250)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481473 Neighboring gene 3-ketodihydrosphingosine reductase Neighboring gene vacuolar protein sorting 4 homolog B Neighboring gene serpin family B member 12 Neighboring gene serpin family B member 13

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cornified envelope ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 
located_in sarcoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
serpin B5
Names
peptidase inhibitor 5
protease inhibitor 5
serine (or cysteine) peptidase inhibitor, clade B, member 5
serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5
serpin peptidase inhibitor, clade B (ovalbumin), member 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_057108.3NP_476449.2  serpin B5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/Swiss-Prot
    P70564
    UniProtKB/TrEMBL
    A6JSV3, G3V6C1
    Related
    ENSRNOP00000003625.6, ENSRNOT00000003625.9
    Conserved Domains (1) summary
    cd02057
    Location:1375
    serpinB5_maspin; serpin family B member 5, mammary serine proteinase inhibitor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    23500203..23520401
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)