Npr2 natriuretic peptide receptor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 116564, updated on 4-Jan-2025

Summary

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Official Symbol: Npr2provided by RGD
Official Full Name: natriuretic peptide receptor 2provided by RGD
Primary source: RGD:620851
See related: EnsemblRapid:ENSRNOG00000015991 AllianceGenome:RGD:620851
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: GC-B; NPR-B
Summary: Enables peptide hormone binding activity. Involved in cGMP-mediated signaling; positive regulation of signal transduction; and wound healing. Predicted to be located in synapse. Predicted to be active in several cellular components, including cilium; neuron projection; and nucleus. Human ortholog(s) of this gene implicated in Miura type epiphyseal chondrodysplasia; acromesomelic dysplasia, Maroteaux type; and essential hypertension. Orthologous to human NPR2 (natriuretic peptide receptor 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Heart (RPKM 77.6), Uterus (RPKM 70.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Npr2 in Genome Data Viewer

Location:: 5q22

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (62678197..62697360)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (57883171..57901590)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (59128186..59147321)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phosphatases modified by LH signaling in ovarian follicles: testing their role in regulating the NPR2 guanylyl cyclasedagger.
Title: Phosphatases modified by LH signaling in ovarian follicles: testing their role in regulating the NPR2 guanylyl cyclase†.
We conclude that FGF rapidly inactivates GC-B by a reversible dephosphorylation mechanism, which may contribute to the signaling network by which activated FGFR3 causes dwarfism.
Title: Dephosphorylation is the mechanism of fibroblast growth factor inhibition of guanylyl cyclase-B.
Cardiac CNP and NPR-B play an important role in exercise preconditioning-mediated cardioprotection against high-intensity exercise-induced myocardial injury in rats.
Title: Elevated C-type natriuretic peptide elicits exercise preconditioning-induced cardioprotection against myocardial injury probably via the up-regulation of NPR-B.
C-type natriuretic peptide reduces cardiac sympathetic neurotransmission via a reduction in neuronal calcium signalling and NE release through the NPR-B receptor. Situations impairing CNP-NPR-B signalling lead to hypertension, tachycardia, and impaired left ventricular systolic function secondary to sympatho-excitation.
Title: C-type natriuretic peptide and natriuretic peptide receptor B signalling inhibits cardiac sympathetic neurotransmission and autonomic function.
Suppression of Npr1, not Npr2 gene function induces hypertrophic growth in cardiomyocytes in vitro.
Title: Suppression of Npr1, not Npr2 gene function induces hypertrophic growth in H9c2 cells in vitro.
Dephosphorylation and inactivation of NPR2 guanylyl cyclase in granulosa cells contributes to the luteinizing hormone-induced decrease in cGMP that causes resumption of meiosis in rat oocytes.
Title: Dephosphorylation and inactivation of NPR2 guanylyl cyclase in granulosa cells contributes to the LH-induced decrease in cGMP that causes resumption of meiosis in rat oocytes.
These data indicate common and distinct properties of particulate guanylyl cyclase receptors in somatotropes.
Title: Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes.
Provide direct evidence for the presence and synthesis of ANP and its receptors in both neuronal and non-neuronal cells within the cochlear spiral ganglion.
Title: Expression patterns of atrial natriuretic peptide and its receptors within the cochlear spiral ganglion of the postnatal rat.
Six phosphorylation sites were identified in rat GC-B (S513, T516, S518, S523, S526, and T529), and all six sites were also identified in human GC-B.
Title: Mass spectrometric identification of phosphorylation sites in guanylyl cyclase A and B.
At postnatal day 1, the vast majority of GC-B (but not GC-A) molecules contain additionally an O-linked carbohydrate modification of about 1 kDa in mass and a further modification of similar size which is resistant to enzymatic removal.
Title: The membrane receptors guanylyl cyclase-A and -B undergo distinctive changes in post-translational modification during brain development.

Submit: New GeneRIF Correction See all GeneRIFs (19)

General gene information

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Markers

Npr2 (e-PCR), detects polymorphism
- UniSTS:526955

BE097058 (e-PCR)
- UniSTS:244595

RH141379 (e-PCR)
- UniSTS:223375

RH141203 (e-PCR)
- UniSTS:223199

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables guanylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanylate cyclase activity	IEA Inferred from Electronic Annotation more info
enables guanylate cyclase activity	ISO Inferred from Sequence Orthology more info
enables hormone binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables natriuretic peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables natriuretic peptide receptor activity	IEA Inferred from Electronic Annotation more info
enables natriuretic peptide receptor activity	ISO Inferred from Sequence Orthology more info
enables peptide hormone binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptide hormone binding	IEA Inferred from Electronic Annotation more info
enables peptide hormone binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables peptide hormone binding	ISO Inferred from Sequence Orthology more info
enables phosphorus-oxygen lyase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in activation of meiosis involved in egg activation	IEA Inferred from Electronic Annotation more info
involved_in activation of meiosis involved in egg activation	ISO Inferred from Sequence Orthology more info
involved_in axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in axonogenesis involved in innervation	IEA Inferred from Electronic Annotation more info
involved_in axonogenesis involved in innervation	ISO Inferred from Sequence Orthology more info
involved_in blood circulation	IEA Inferred from Electronic Annotation more info
involved_in blood circulation	ISO Inferred from Sequence Orthology more info
involved_in blood vessel development	ISO Inferred from Sequence Orthology more info
involved_in blood vessel remodeling	IEA Inferred from Electronic Annotation more info
involved_in blood vessel remodeling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within bone development	ISO Inferred from Sequence Orthology more info
involved_in bone growth	ISO Inferred from Sequence Orthology more info
involved_in c-di-GMP signaling	IEA Inferred from Electronic Annotation more info
involved_in c-di-GMP signaling	ISO Inferred from Sequence Orthology more info
involved_in cGMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cGMP biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of cGMP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cGMP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in cGMP-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in cartilage development	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cGMP	IEA Inferred from Electronic Annotation more info
involved_in cellular response to cGMP	ISO Inferred from Sequence Orthology more info
involved_in cellular response to granulocyte macrophage colony-stimulating factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to granulocyte macrophage colony-stimulating factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to peptide	IEA Inferred from Electronic Annotation more info
involved_in cellular response to peptide	ISO Inferred from Sequence Orthology more info
involved_in chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in chondrocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in chondrocyte proliferation	IEA Inferred from Electronic Annotation more info
involved_in chondrocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in chromosome organization	IEA Inferred from Electronic Annotation more info
involved_in chromosome organization	ISO Inferred from Sequence Orthology more info
involved_in collateral sprouting	IEA Inferred from Electronic Annotation more info
involved_in collateral sprouting	ISO Inferred from Sequence Orthology more info
involved_in cumulus cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cumulus cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in digestive tract development	ISO Inferred from Sequence Orthology more info
involved_in digestive tract morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in digestive tract morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in endochondral ossification	IEA Inferred from Electronic Annotation more info
involved_in endochondral ossification	ISO Inferred from Sequence Orthology more info
involved_in epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in execution phase of apoptosis	IEA Inferred from Electronic Annotation more info
involved_in execution phase of apoptosis	ISO Inferred from Sequence Orthology more info
involved_in female genitalia development	IEA Inferred from Electronic Annotation more info
involved_in female genitalia development	ISO Inferred from Sequence Orthology more info
involved_in gastric emptying	IEA Inferred from Electronic Annotation more info
involved_in gastric emptying	ISO Inferred from Sequence Orthology more info
involved_in genitalia morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in genitalia morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in germ cell development	ISO Inferred from Sequence Orthology more info
involved_in growth plate cartilage development	IEA Inferred from Electronic Annotation more info
involved_in growth plate cartilage development	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in limb development	ISO Inferred from Sequence Orthology more info
involved_in limb morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in limb morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in lymph vessel development	IEA Inferred from Electronic Annotation more info
involved_in lymph vessel development	ISO Inferred from Sequence Orthology more info
acts_upstream_of meiotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in meiotic cell cycle process involved in oocyte maturation	IEA Inferred from Electronic Annotation more info
involved_in meiotic cell cycle process involved in oocyte maturation	ISO Inferred from Sequence Orthology more info
involved_in multicellular organism growth	IEA Inferred from Electronic Annotation more info
involved_in multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of meiotic cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of meiotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of oocyte maturation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of oocyte maturation	ISO Inferred from Sequence Orthology more info
involved_in nerve development	ISO Inferred from Sequence Orthology more info
involved_in neuron apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in neuronal action potential	IEA Inferred from Electronic Annotation more info
involved_in neuronal action potential	ISO Inferred from Sequence Orthology more info
involved_in oocyte development	ISO Inferred from Sequence Orthology more info
involved_in ossification	IEA Inferred from Electronic Annotation more info
involved_in ovarian follicle development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cGMP-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of platelet-derived growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in post-anal tail morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in post-anal tail morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in receptor guanylyl cyclase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor guanylyl cyclase signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in receptor guanylyl cyclase signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in receptor guanylyl cyclase signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to fibroblast growth factor	IEA Inferred from Electronic Annotation more info
involved_in response to fibroblast growth factor	ISO Inferred from Sequence Orthology more info
involved_in response to hormone	ISO Inferred from Sequence Orthology more info
involved_in response to luteinizing hormone	IEA Inferred from Electronic Annotation more info
involved_in response to luteinizing hormone	ISO Inferred from Sequence Orthology more info
involved_in response to salt	IEA Inferred from Electronic Annotation more info
involved_in response to salt	ISO Inferred from Sequence Orthology more info
involved_in response to wounding	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of sound	IEA Inferred from Electronic Annotation more info
involved_in sensory perception of sound	ISO Inferred from Sequence Orthology more info
involved_in single fertilization	ISO Inferred from Sequence Orthology more info
involved_in smooth muscle tissue development	IEA Inferred from Electronic Annotation more info
involved_in smooth muscle tissue development	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	ISO Inferred from Sequence Orthology more info
involved_in startle response	IEA Inferred from Electronic Annotation more info
involved_in startle response	ISO Inferred from Sequence Orthology more info
involved_in vacuole organization	IEA Inferred from Electronic Annotation more info
involved_in vacuole organization	ISO Inferred from Sequence Orthology more info
involved_in vascular wound healing	IEA Inferred from Electronic Annotation more info
involved_in vascular wound healing	ISO Inferred from Sequence Orthology more info
involved_in vasculogenesis	IEA Inferred from Electronic Annotation more info
involved_in vasculogenesis	ISO Inferred from Sequence Orthology more info
involved_in vestibulocochlear nerve development	ISO Inferred from Sequence Orthology more info
involved_in vestibulocochlear nerve maturation	IEA Inferred from Electronic Annotation more info
involved_in vestibulocochlear nerve maturation	ISO Inferred from Sequence Orthology more info
involved_in white fat cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in white fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in wound healing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cilium	IEA Inferred from Electronic Annotation more info
is_active_in cilium	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in neuron projection	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: atrial natriuretic peptide receptor 2

Names: ANP-B; ANPR-B; ANPRB; atrial natriuretic peptide B-type receptor; atrial natriuretic peptide receptor B; atrial natriuretic peptide receptor type B; guanylate cyclase B; natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B); natriuretic peptide receptor-B

NP_446290.1

EC 4.6.1.2

XP_006238072.1

EC 4.6.1.2

XP_063143136.1

EC 4.6.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053838.1 → NP_446290.1 atrial natriuretic peptide receptor 2 precursor

See identical proteins and their annotated locations for NP_446290.1

Status: PROVISIONAL

Source sequence(s)

M26896

UniProtKB/Swiss-Prot

P16067

UniProtKB/TrEMBL

A6IJ41

Related

ENSRNOP00000086809.1, ENSRNOT00000112447.2

Conserved Domains (4) summary

smart00044
Location:825 → 1009

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

cd14042
Location:518 → 792

PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B

cd06384
Location:26 → 421

PBP1_NPR_B; ligand-binding domain of type B natriuretic peptide receptor

pfam07701
Location:798 → 846

HNOBA; Heme NO binding associated

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

62678197..62697360

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006238010.5 → XP_006238072.1 atrial natriuretic peptide receptor 2 isoform X1

UniProtKB/TrEMBL

A0A8L2UJL6, A6IJ41

Related

ENSRNOP00000021802.3, ENSRNOT00000021802.7

Conserved Domains (6) summary

smart00044
Location:800 → 984

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

cd14042
Location:486 → 767

PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B

pfam00211
Location:827 → 1013

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam01094
Location:44 → 397

ANF_receptor; Receptor family ligand binding region

pfam07701
Location:776 → 821

HNOBA; Heme NO binding associated

cl10011
Location:26 → 421

Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
XM_063287066.1 → XP_063143136.1 atrial natriuretic peptide receptor 2 isoform X2