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Ccnc cyclin C [ Rattus norvegicus (Norway rat) ]

Gene ID: 114839, updated on 27-Nov-2024

Summary

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Official Symbol
Ccncprovided by RGD
Official Full Name
cyclin Cprovided by RGD
Primary source
RGD:70905
See related
EnsemblRapid:ENSRNOG00000007719 AllianceGenome:RGD:70905
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Contributes to ubiquitin protein ligase activity. Involved in negative regulation of triglyceride metabolic process and protein ubiquitination. Part of ubiquitin ligase complex. Orthologous to human CCNC (cyclin C). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 129.0), Brain (RPKM 120.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ccnc in Genome Data Viewer
Location:
5q21
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (40063589..40081731)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (35266828..35284943)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (35865598..35883732)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein eL29-like Neighboring gene PR/SET domain 13 Neighboring gene uncharacterized LOC120102842 Neighboring gene thiosulfate sulfurtransferase like domain containing 3 Neighboring gene uncharacterized LOC134478949 Neighboring gene ubiquitin specific peptidase 45

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. [Influence of aerosols on the expression of cyclin B1, cyclin C and proliferating cell nuclear antigen in wound tissue healing of burned rat models]. Zhang T, et al. Zhonghua Wai Ke Za Zhi, 2005 Oct 1. PMID 16271231
  2. Cyclin C and cyclin dependent kinases 1, 2 and 3 in thrombin-induced neuronal cell cycle progression and apoptosis. Rao HV, et al. Neurosci Lett, 2009 Feb 6. PMID 19103257, Free PMC Article
  3. Molecular cloning and chromosomal localization of the human cyclin C (CCNC) and cyclin E (CCNE) genes: deletion of the CCNC gene in human tumors. Li H, et al. Genomics, 1996 Mar 1. PMID 8833152
  4. Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3). Demetrick DJ, et al. Cytogenet Cell Genet, 1995. PMID 7698009
  5. Cyclin G: a new mammalian cyclin with homology to fission yeast Cig1. Tamura K, et al. Oncogene, 1993 Aug. PMID 8336937

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclin-dependent protein serine/threonine kinase regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in G0 to G1 transition IEA
Inferred from Electronic Annotation
more info
  
involved_in G0 to G1 transition ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of triglyceride metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of CKM complex IEA
Inferred from Electronic Annotation
more info
  
part_of CKM complex ISO
Inferred from Sequence Orthology
more info
  
part_of cyclin-dependent protein kinase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
  
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex IEA
Inferred from Electronic Annotation
more info
  
part_of mediator complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cyclin-C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100472.1 → NP_001093942.1  cyclin-C

    See identical proteins and their annotated locations for NP_001093942.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    P39947
    UniProtKB/TrEMBL
    A6IIE2, G3V738
    Related
    ENSRNOP00000011442.5, ENSRNOT00000011442.8
    Conserved Domains (2) summary
    cd20513
    Location:40 → 146
    CYCLIN_CCNC_rpt1; first cyclin box found in cyclin-C (CCNC) and similar proteins
    cd20514
    Location:154 → 245
    CYCLIN_CCNC_rpt2; second cyclin box found in cyclin-C (CCNC) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    40063589..40081731
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006237937.5 → XP_006237999.1  cyclin-C isoform X2

    See identical proteins and their annotated locations for XP_006237999.1

    UniProtKB/Swiss-Prot
    P39947
    UniProtKB/TrEMBL
    A0A8I6A408, A6IIE3
    Related
    ENSRNOP00000086557.1, ENSRNOT00000110130.2
    Conserved Domains (2) summary
    cd20513
    Location:40 → 146
    CYCLIN_CCNC_rpt1; first cyclin box found in cyclin-C (CCNC) and similar proteins
    cd20514
    Location:154 → 245
    CYCLIN_CCNC_rpt2; second cyclin box found in cyclin-C (CCNC) and similar proteins

  2. XM_039109128.2 → XP_038965056.1  cyclin-C isoform X2

    UniProtKB/Swiss-Prot
    P39947
    UniProtKB/TrEMBL
    A0A8I6A408, A6IIE3
    Conserved Domains (2) summary
    cd20513
    Location:40 → 146
    CYCLIN_CCNC_rpt1; first cyclin box found in cyclin-C (CCNC) and similar proteins
    cd20514
    Location:154 → 245
    CYCLIN_CCNC_rpt2; second cyclin box found in cyclin-C (CCNC) and similar proteins

  3. XM_063287061.1 → XP_063143131.1  cyclin-C isoform X1

    Related
    ENSRNOP00000095999.1, ENSRNOT00000107276.2

  4. XM_063287062.1 → XP_063143132.1  cyclin-C isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P39947.2 GenPept UniProtKB/Swiss-Prot:P39947

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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