U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pitpnb phosphatidylinositol transfer protein, beta [ Rattus norvegicus (Norway rat) ]

Gene ID: 114561, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
Pitpnbprovided by RGD
Official Full Name
phosphatidylinositol transfer protein, betaprovided by RGD
Primary source
RGD:620143
See related
EnsemblRapid:ENSRNOG00000000665 AllianceGenome:RGD:620143
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables phospholipid binding activity and phospholipid transporter activity. Involved in phospholipid transport. Located in Golgi membrane and endoplasmic reticulum membrane. Orthologous to human PITPNB (phosphatidylinositol transfer protein beta). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Heart (RPKM 182.2), Liver (RPKM 139.0) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Pitpnb in Genome Data Viewer
Location:
12q16
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (50909140..50958193, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (45249308..45298388, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (51279194..51341752, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102552958 Neighboring gene uncharacterized LOC100912310 Neighboring gene uncharacterized LOC134481215 Neighboring gene MN1 proto-oncogene, transcriptional regulator Neighboring gene uncharacterized LOC134481214 Neighboring gene uncharacterized LOC102554233 Neighboring gene tetratricopeptide repeat domain 28 Neighboring gene uncharacterized LOC102553561

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Cloning of a cDNA encoding a second phosphatidylinositol transfer protein of rat brain by complementation of the yeast sec14 mutation. Tanaka S, et al. J Biochem, 1994 May. PMID 7961615
  2. Differential expression of a C-terminal splice variant of phosphatidylinositol transfer protein beta lacking the constitutive-phosphorylated Ser262 that localizes to the Golgi compartment. Morgan CP, et al. Biochem J, 2006 Sep 15. PMID 16780419, Free PMC Article
  3. Phosphatidylinositol transfer protein expression altered by aging and Parkinson disease. Chalimoniuk M, et al. Cell Mol Neurobiol, 2006 Oct-Nov. PMID 16779671
  4. Genetic ablation of phosphatidylinositol transfer protein function in murine embryonic stem cells. Alb JG Jr, et al. Mol Biol Cell, 2002 Mar. PMID 11907258, Free PMC Article
  5. Dynamics of lipid transfer by phosphatidylinositol transfer proteins in cells. Shadan S, et al. Traffic, 2008 Sep. PMID 18636990, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. in rat liver, the single gene for PITPbeta gives rise to seven distinct protein species that can be resolved on the basis of their charge differences
    Title: Differential expression of a C-terminal splice variant of phosphatidylinositol transfer protein beta lacking the constitutive-phosphorylated Ser262 that localizes to the Golgi compartment.
  2. Lower protein expression of PI-TP(alpha and beta) in aged brain and in PD.
    Title: Phosphatidylinositol transfer protein expression altered by aging and Parkinson disease.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylcholine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylcholine binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylcholine binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylcholine binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylcholine transfer activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylcholine transfer activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylcholine transfer activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatidylcholine transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylcholine transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylcholine transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol transfer activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol transfer activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol transfer activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables phosphatidylinositol transfer activity ISO
Inferred from Sequence Orthology
more info
  
enables phospholipid transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables sphingomyelin transfer activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in intermembrane lipid transfer IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phospholipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid transport ISO
Inferred from Sequence Orthology
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
phosphatidylinositol transfer protein beta isoform
Names
PI-TP-beta
phosphotidylinositol transfer protein, beta
ptdIns transfer protein beta
ptdInsTP beta

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053742.2 → NP_446194.1  phosphatidylinositol transfer protein beta isoform

    See identical proteins and their annotated locations for NP_446194.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/Swiss-Prot
    P53812, Q6P7S3
    UniProtKB/TrEMBL
    A6J279
    Related
    ENSRNOP00000078649.1, ENSRNOT00000115325.2
    Conserved Domains (1) summary
    cd08888
    Location:3 → 259
    SRPBCC_PITPNA-B_like; Lipid-binding SRPBCC domain of mammalian PITPNA, -B, and related proteins (Class I PITPs)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    50909140..50958193 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006249522.5 → XP_006249584.1  phosphatidylinositol transfer protein beta isoform isoform X3

    See identical proteins and their annotated locations for XP_006249584.1

    UniProtKB/TrEMBL
    D3ZCD4
    Related
    ENSRNOP00000050368.5, ENSRNOT00000052202.6
    Conserved Domains (1) summary
    cd08888
    Location:3 → 258
    SRPBCC_PITPNA-B_like; Lipid-binding SRPBCC domain of mammalian PITPNA, -B, and related proteins (Class I PITPs)

  2. XM_063270991.1 → XP_063127061.1  phosphatidylinositol transfer protein beta isoform isoform X1

  3. XM_063270992.1 → XP_063127062.1  phosphatidylinositol transfer protein beta isoform isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53812.2 GenPept UniProtKB/Swiss-Prot:P53812

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous