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LOC114515523 olfactory receptor enhancer Sifnos [ Mus musculus (house mouse) ]

Gene ID: 114515523, updated on 9-Aug-2024

Summary

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Gene symbol
LOC114515523
Gene description
olfactory receptor enhancer Sifnos
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rr366821
Summary
This genomic region includes one of several intergenic enhancers, known as Greek islands, which aggregate to form an interchromosomal hub that enables expression of a single olfactory receptor (OR) gene in olfactory sensory neurons. While all of the other OR gene clusters are sequestered in a large heterochromatic domain, this multi-enhancer interaction network evades heterochromatic silencing by associating with the transcription factors Lhx2 (LIM homeobox 2) and Ebf (EBF transcription factor), which bind in a functionally cooperative manner to allow expression of the active OR gene. The Greek island included in this genomic region, Sifnos, was validated as a functional enhancer by reporter assays in olfactory sensory neurons of transgenic zebrafish embryos. This locus also includes an enhancer that was validated by the STARR-seq (self-transcribing active regulatory region sequencing) reporter assay in metastable (SL) mouse embryonic stem cells, where it was defined as a C1 class enhancer that overlaps an active chromatin signature. [provided by RefSeq, Jul 2023]
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Genomic context

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See LOC114515523 in Genome Data Viewer
Location:
chromosome: 11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (87856387..87858390)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (87965561..87966605)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 4 subfamily D member 1 Neighboring gene ubiquitin-conjugating enzyme MHR6BN pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3007 Neighboring gene dynein light chain LC8-type 2 Neighboring gene predicted gene, 38610

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Chromosomes come together to help mice distinguish odours. Spitz F. Nature, 2019 Jan. PMID 30666054
  2. Monoallelic expression of olfactory receptors. Monahan K, et al. Annu Rev Cell Dev Biol, 2015. PMID 26359778, Free PMC Article
  3. How keeping active pays off in the olfactory system. Monahan K, et al. Elife, 2012 Dec 13. PMID 23240088, Free PMC Article
  4. LHX2- and LDB1-mediated trans interactions regulate olfactory receptor choice. Monahan K, et al. Nature, 2019 Jan. PMID 30626972, Free PMC Article
  5. Cooperative interactions enable singular olfactory receptor expression in mouse olfactory neurons. Monahan K, et al. Elife, 2017 Sep 21. PMID 28933695, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Other Names

  • STARR-seq mESC enhancer starr_30301
  • Sifnos Greek island enhancer
  • regulatory region 366821

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_064614.2 

    Range
    101..2104
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    87856387..87858390
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version