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arpc4 actin related protein 2/3 complex, subunit 4 [ Danio rerio (zebrafish) ]

Gene ID: 114456, updated on 4-Jan-2025

Summary

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Official Symbol
arpc4provided by ZNC
Official Full Name
actin related protein 2/3 complex, subunit 4provided by ZNC
Primary source
ZFIN:ZDB-GENE-010724-9
See related
Ensembl:ENSDARG00000054063 AllianceGenome:ZFIN:ZDB-GENE-010724-9
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fa07b12; zgc:77932; wu:fa07b12
Summary
Predicted to enable actin filament binding activity. Predicted to be involved in Arp2/3 complex-mediated actin nucleation. Predicted to be part of Arp2/3 protein complex. Orthologous to human ARPC4 (actin related protein 2/3 complex subunit 4). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See arpc4 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (40762429..40768654, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (40764893..40771118, complement)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene prolyl 4-hydroxylase, transmembrane b Neighboring gene myosin, heavy chain b Neighboring gene si:ch211-157b11.8 Neighboring gene H1.10 linker histone

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Knockdown of zebrafish Fancd2 causes developmental abnormalities via p53-dependent apoptosis. Liu TX, et al. Dev Cell, 2003 Dec. PMID 14667412
  2. Differential Requirement of Gata2a and Gata2b for Primitive and Definitive Myeloid Development in Zebrafish. Peña OA, et al. Front Cell Dev Biol, 2021. PMID 34589480, Free PMC Article
  3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Arp2/3 protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
actin-related protein 2/3 complex subunit 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205537.1 → NP_991100.1  actin-related protein 2/3 complex subunit 4

    See identical proteins and their annotated locations for NP_991100.1

    Status: PROVISIONAL

    Source sequence(s)
    BC065899
    UniProtKB/TrEMBL
    A8E5F5, Q6NZZ2
    Related
    ENSDARP00000155849.1, ENSDART00000184668.1
    Conserved Domains (1) summary
    pfam05856
    Location:1 → 166
    ARPC4; ARP2/3 complex 20 kDa subunit (ARPC4)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    40762429..40768654 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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