copb2 COPI coat complex subunit beta 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: copb2provided by ZNC
Official Full Name: COPI coat complex subunit beta 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-010724-7
See related: Ensembl:ENSDARG00000038743 AllianceGenome:ZFIN:ZDB-GENE-010724-7
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: sb:cb121; wu:fb30f06
Summary: Predicted to enable structural molecule activity. Acts upstream of or within several processes, including Golgi localization; endoplasmic reticulum localization; and notochord development. Predicted to be located in Golgi membrane and cytoplasmic vesicle. Predicted to be part of COPI vesicle coat. Is expressed in several structures, including axial mesoderm; cardiovascular system; digestive system; fin; and nervous system. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 19. Orthologous to human COPB2 (COPI coat complex subunit beta 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (38997357..39015074, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (39031718..39049435, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

COPB2 loss of function causes a coatopathy with osteoporosis and developmental delay.
Title: COPB2 loss of function causes a coatopathy with osteoporosis and developmental delay.

Submit: New GeneRIF Correction

General gene information

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Markers

AI415987 (e-PCR)
- UniSTS:206634

fc48d01.y1 (e-PCR)
- UniSTS:193981

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Golgi localization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endoplasmic reticulum localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intra-Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intracellular protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within notochord development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within somite development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of COPI vesicle coat	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of membrane coat	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: coatomer subunit beta'

Names: coatomer protein complex, subunit beta 2; dop; dopey

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001001940.1 → NP_001001940.1 coatomer subunit beta'

See identical proteins and their annotated locations for NP_001001940.1

Status: PROVISIONAL

Source sequence(s)

AY294011

UniProtKB/TrEMBL

Q6JWU7

Related

ENSDARP00000044330.6, ENSDART00000044331.7

Conserved Domains (4) summary

COG2319
Location:24 → 428

WD40; WD40 repeat [General function prediction only]

cd00200
Location:8 → 297

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam04053
Location:320 → 763

Coatomer_WDAD; Coatomer WD associated region

sd00039
Location:103 → 140

7WD40; WD40 repeat [structural motif]