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spry4 sprouty homolog 4 (Drosophila) [ Danio rerio (zebrafish) ]

Gene ID: 114437, updated on 9-Dec-2024

Summary

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Official Symbol
spry4provided by ZNC
Official Full Name
sprouty homolog 4 (Drosophila)provided by ZNC
Primary source
ZFIN:ZDB-GENE-010803-2
See related
Ensembl:ENSDARG00000068732 AllianceGenome:ZFIN:ZDB-GENE-010803-2
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb511; zSpry4; sprouty4; wu:fb92b06
Summary
Acts upstream of or within several processes, including negative regulation of fibroblast growth factor receptor signaling pathway; rhombomere formation; and skeletal muscle fiber development. Predicted to be located in membrane. Predicted to be active in cytosol. Is expressed in several structures, including immature eye; mesoderm; nervous system; neural keel; and neural plate. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 17 with or without anosmia. Orthologous to human SPRY4 (sprouty RTK signaling antagonist 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See spry4 in Genome Data Viewer
Location:
chromosome: 21
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (44684577..44691071)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (44605062..44610571, complement)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene microRNA mir-222b Neighboring gene transmembrane protein 164 Neighboring gene AMMECR nuclear protein 1 Neighboring gene kinesin family member 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Species-specific contribution of volumetric growth and tissue convergence to posterior body elongation in vertebrates. Steventon B, et al. Development, 2016 May 15. PMID 26989170
  2. Regenerative neurogenesis from neural progenitor cells requires injury-induced expression of Gata3. Kizil C, et al. Dev Cell, 2012 Dec 11. PMID 23168169
  3. Fgf signaling instructs position-dependent growth rate during zebrafish fin regeneration. Lee Y, et al. Development, 2005 Dec. PMID 16251209
  4. Size-reduced embryos reveal a gradient scaling-based mechanism for zebrafish somite formation. Ishimatsu K, et al. Development, 2018 Jun 11. PMID 29769221, Free PMC Article
  5. Mutation of the atrophin2 gene in the zebrafish disrupts signaling by fibroblast growth factor during development of the inner ear. Asai Y, et al. Proc Natl Acad Sci U S A, 2006 Jun 13. PMID 16754885, Free PMC Article

See all (97) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hindbrain patterning requires fine-tuning of early krox20 transcription by Sprouty 4.
    Title: Hindbrain patterning requires fine-tuning of early krox20 transcription by Sprouty 4.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in animal organ development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within hemopoiesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of fibroblast growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of fibroblast growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
  
acts_upstream_of_or_within regulation of fibroblast growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within rhombomere formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within skeletal muscle fiber development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein sprouty homolog 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131826.2 → NP_571901.2  protein sprouty homolog 4

    Status: VALIDATED

    Source sequence(s)
    CABZ01085217, EH447258
    UniProtKB/TrEMBL
    A0A8M9PQ80, F1QZW4, Q90XH4
    Related
    ENSDARP00000090302.3, ENSDART00000099528.4
    Conserved Domains (1) summary
    pfam05210
    Location:179 → 276
    Sprouty; Sprouty protein (Spry)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    44684577..44691071
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021468746.2 → XP_021324421.1  protein sprouty homolog 4 isoform X1

    UniProtKB/TrEMBL
    A0A8M9PQ80, F1QZW4, Q90XH4
    Conserved Domains (1) summary
    pfam05210
    Location:179 → 276
    Sprouty; Sprouty protein (Spry)
Nucleotide Protein Strain
Heading Accession and Version

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