U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

f7 coagulation factor VII [ Danio rerio (zebrafish) ]

Gene ID: 114423, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
f7provided by ZNC
Official Full Name
coagulation factor VIIprovided by ZNC
Primary source
ZFIN:ZDB-GENE-010814-1
See related
Ensembl:ENSDARG00000034862 AllianceGenome:ZFIN:ZDB-GENE-010814-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fb59f04; zgc:109870
Summary
Predicted to enable serine-type endopeptidase activity. Acts upstream of or within blood coagulation, fibrin clot formation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in blood plasma; liver; and yolk syncytial layer. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebral infarction; diabetes mellitus (multiple); factor VII deficiency; and obesity. Orthologous to human F7 (coagulation factor VII). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (119960..125246)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (119960..125246)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene glycoprotein A33 (transmembrane), paralog a Neighboring gene coagulation factor VII, like Neighboring gene coagulation factor VIIi Neighboring gene coagulation factor X

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Demonstration of the extrinsic coagulation pathway in teleostei: identification of zebrafish coagulation factor VII. Sheehan J, et al. Proc Natl Acad Sci U S A, 2001 Jul 17. PMID 11459993, Free PMC Article
  2. Genetic analysis of hemostasis and thrombosis using vascular occlusion. Gregory M, et al. Blood Cells Mol Dis, 2002 Nov-Dec. PMID 12547218
  3. Role of hepsin in factor VII activation in zebrafish. Khandekar G, et al. Blood Cells Mol Dis, 2014 Jan. PMID 23954211
  4. Comprehensive analysis of blood coagulation pathways in teleostei: evolution of coagulation factor genes and identification of zebrafish factor VIIi. Hanumanthaiah R, et al. Blood Cells Mol Dis, 2002 Jul-Aug. PMID 12482404
  5. Tetramethylpyrazine Protects Endothelial Injury and Antithrombosis via Antioxidant and Antiapoptosis in HUVECs and Zebrafish. Zhang Y, et al. Oxid Med Cell Longev, 2022. PMID 35898617, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in blood coagulation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within blood coagulation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within blood coagulation, fibrin clot formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
coagulation factor VII
Names
clotting factor
NP_571894.2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131819.2 → NP_571894.2  coagulation factor VII precursor

    See identical proteins and their annotated locations for NP_571894.2

    Status: PROVISIONAL

    Source sequence(s)
    BC095023
    UniProtKB/TrEMBL
    Q504H3
    Related
    ENSDARP00000018993.7, ENSDART00000013209.7
    Conserved Domains (5) summary
    smart00020
    Location:195 → 424
    Tryp_SPc; Trypsin-like serine protease
    smart00069
    Location:19 → 82
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    cd00054
    Location:86 → 121
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00190
    Location:196 → 427
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam14670
    Location:131 → 166
    FXa_inhibition; Coagulation Factor Xa inhibitory site

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    119960..125246
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.