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Acp5 acid phosphatase 5, tartrate resistant [ Mus musculus (house mouse) ]

Gene ID: 11433, updated on 27-Nov-2024

Summary

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Official Symbol
Acp5provided by MGI
Official Full Name
acid phosphatase 5, tartrate resistantprovided by MGI
Primary source
MGI:MGI:87883
See related
Ensembl:ENSMUSG00000001348 AllianceGenome:MGI:87883
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TRAP; TRACP
Summary
Enables acid phosphatase activity. Acts upstream of or within several processes, including bone resorption; negative regulation of cytokine production; and response to bacterium. Located in lysosome. Is expressed in several structures, including alimentary system; limb; liver; skeleton; and skin. Human ortholog(s) of this gene implicated in spondylometaphyseal dysplasia. Orthologous to human ACP5 (acid phosphatase 5, tartrate resistant). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 123.7), colon adult (RPKM 116.7) and 17 other tissues See more
Orthologs
human all
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Genomic context

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See Acp5 in Genome Data Viewer
Location:
9 A3; 9 8.38 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (22038023..22047042, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (22126727..22135746, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene calponin 1 Neighboring gene STARR-positive B cell enhancer ABC_E2285 Neighboring gene microRNA 7084 Neighboring gene STARR-positive B cell enhancer ABC_E11403 Neighboring gene ELF1 homolog, elongation factor 1 Neighboring gene predicted gene, 39306 Neighboring gene STARR-positive B cell enhancer ABC_E1380 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class Y-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Analysis of distinct tartrate-resistant acid phosphatase promoter regions in transgenic mice. Pan W, et al. J Biol Chem, 2005 Feb 11. PMID 15590658
  2. Role of tartrate-resistant acid phosphatase (TRAP) in long bone development. Blumer MJ, et al. Mech Dev, 2012 Jul. PMID 22579636, Free PMC Article
  3. Assessment the levels of tartrate-resistant acid phosphatase (TRAP) on mice fed with eggshell calcium citrate malate. Yu Y, et al. Int J Biol Macromol, 2013 Jul. PMID 23603074
  4. A novel in vitro loading system to produce supraphysiologic oscillatory fluid shear stress. Oest ME, et al. J Biomech, 2014 Jan 22. PMID 24275439, Free PMC Article
  5. Acid phosphatase 5 is responsible for removing the mannose 6-phosphate recognition marker from lysosomal proteins. Sun P, et al. Proc Natl Acad Sci U S A, 2008 Oct 28. PMID 18940929, Free PMC Article

See all (115) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tartrate-resistant acid phosphatase (TRAP/ACP5) promotes bone length, regulates cortical and trabecular bone mass, and maintains growth plate architecture and width in a sex- and site-specific manner in mice.
    Title: Tartrate-resistant acid phosphatase (TRAP/ACP5) promotes bone length, regulates cortical and trabecular bone mass, and maintains growth plate architecture and width in a sex- and site-specific manner in mice.
  2. Inhibition of tartrate-resistant acid phosphatase 5 can prevent cardiac fibrosis after myocardial infarction.
    Title: Inhibition of tartrate-resistant acid phosphatase 5 can prevent cardiac fibrosis after myocardial infarction.
  3. Tartrate resistant acid phosphatase 5 (TRAP5) mediates immune cell recruitment in a murine model of pulmonary bacterial infection.
    Title: Tartrate resistant acid phosphatase 5 (TRAP5) mediates immune cell recruitment in a murine model of pulmonary bacterial infection.
  4. TRAP and nidogen-2 co-localized in adipose tissue cells in situ.
    Title: The growth factor-like adipokine tartrate-resistant acid phosphatase 5a interacts with the rod G3 domain of adipocyte-produced nidogen-2.
  5. Uteroferrin is a cytokine secreted by uterine glands in response to progesterone that promotes fetal erythropoiesis at various stages of pregnancy.
    Title: Pregnancy-secreted Acid phosphatase, uteroferrin, enhances fetal erythropoiesis.
  6. Supraphysiologic oscillatory fluid shear induces upregulation of osteoclastic activity, measured by tartrate-resistant acid phosphatase activity and formation of mineral resorption pits.
    Title: A novel in vitro loading system to produce supraphysiologic oscillatory fluid shear stress.
  7. Pax6 binds endogenously to the proximal region of the tartrate acid phosphatase (TRAP) gene promoter and suppresses nuclear factor of activated T cells c1 (NFATc1)-induced TRAP gene expression.
    Title: The paired-box homeodomain transcription factor Pax6 binds to the upstream region of the TRAP gene promoter and suppresses receptor activator of NF-κB ligand (RANKL)-induced osteoclast differentiation.
  8. Serum TRAP levels were lower in mice receiving eggshell calcium citrate malate than those receiving eggshells calcium malate.
    Title: Assessment the levels of tartrate-resistant acid phosphatase (TRAP) on mice fed with eggshell calcium citrate malate.
  9. tartrate resistant acid phosphatase
    Title: Foreign body giant cells and osteoclasts are TRAP positive, have podosome-belts and both require OC-STAMP for cell fusion.
  10. TRAP is not essential for the formation of the epiphyseal vascular network.
    Title: Role of tartrate-resistant acid phosphatase (TRAP) in long bone development.
Submit: New GeneRIF Correction See all GeneRIFs (25)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acid phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acid phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acid phosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables acid phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables ferric iron binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ferric iron binding ISO
Inferred from Sequence Orthology
more info
  
enables ferric iron binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ferrous iron binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ferrous iron binding ISO
Inferred from Sequence Orthology
more info
  
enables ferrous iron binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within bone morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in bone resorption IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within bone resorption IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of interleukin-1 beta production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of interleukin-12 production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of macrophage cytokine production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of interleukin-1 beta production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of interleukin-12 production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of macrophage cytokine production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of nitric oxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of superoxide anion generation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of nitric oxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to cytokine IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of superoxide anion generation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lysosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
tartrate-resistant acid phosphatase type 5
Names
TR-AP
acid phosphatase type V
tartrate-resistant acid ATPase
trATPase
type 5 acid phosphatase
NP_001095874.1
NP_001095875.1
NP_031414.1
XP_006510007.1
XP_006510008.1
XP_006510009.1
XP_011240686.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001102404.1 → NP_001095874.1  tartrate-resistant acid phosphatase type 5 precursor

    See identical proteins and their annotated locations for NP_001095874.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same isoform.
    Source sequence(s)
    AK010865, AK011915, BQ031772, BY084869
    Consensus CDS
    CCDS22923.1
    UniProtKB/Swiss-Prot
    Q05117
    Related
    ENSMUSP00000065425.7, ENSMUST00000069330.14
    Conserved Domains (1) summary
    cd07378
    Location:28 → 313
    MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain

  2. NM_001102405.1 → NP_001095875.1  tartrate-resistant acid phosphatase type 5 precursor

    See identical proteins and their annotated locations for NP_001095875.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same isoform.
    Source sequence(s)
    AK010865, AK011915, BQ031772, BY107232
    Consensus CDS
    CCDS22923.1
    UniProtKB/Swiss-Prot
    Q05117
    Related
    ENSMUSP00000127128.2, ENSMUST00000165735.9
    Conserved Domains (1) summary
    cd07378
    Location:28 → 313
    MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain

  3. NM_007388.3 → NP_031414.1  tartrate-resistant acid phosphatase type 5 precursor

    See identical proteins and their annotated locations for NP_031414.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same isoform.
    Source sequence(s)
    AK010865, AK011915, BG076865, BQ031772
    Consensus CDS
    CCDS22923.1
    UniProtKB/Swiss-Prot
    Q05117
    Related
    ENSMUSP00000110970.3, ENSMUST00000115315.3
    Conserved Domains (1) summary
    cd07378
    Location:28 → 313
    MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    22038023..22047042 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242384.2 → XP_011240686.1  tartrate-resistant acid phosphatase type 5 isoform X1

    See identical proteins and their annotated locations for XP_011240686.1

    UniProtKB/Swiss-Prot
    Q05117
    Conserved Domains (1) summary
    cd07378
    Location:28 → 313
    MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain

  2. XM_006509944.3 → XP_006510007.1  tartrate-resistant acid phosphatase type 5 isoform X1

    See identical proteins and their annotated locations for XP_006510007.1

    UniProtKB/Swiss-Prot
    Q05117
    Conserved Domains (1) summary
    cd07378
    Location:28 → 313
    MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain

  3. XM_006509945.3 → XP_006510008.1  tartrate-resistant acid phosphatase type 5 isoform X1

    See identical proteins and their annotated locations for XP_006510008.1

    UniProtKB/Swiss-Prot
    Q05117
    Conserved Domains (1) summary
    cd07378
    Location:28 → 313
    MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain

  4. XM_006509946.3 → XP_006510009.1  tartrate-resistant acid phosphatase type 5 isoform X1

    See identical proteins and their annotated locations for XP_006510009.1

    UniProtKB/Swiss-Prot
    Q05117
    Related
    ENSMUSP00000149597.2, ENSMUST00000213815.2
    Conserved Domains (1) summary
    cd07378
    Location:28 → 313
    MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q05117.2 GenPept UniProtKB/Swiss-Prot:Q05117

Gene LinkOut

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