Yme1l1 YME1-like 1 ATPase [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Yme1l1provided by RGD
Full Name: YME1-like 1 ATPaseprovided by RGD
Primary source: RGD:620764
See related: EnsemblRapid:ENSRNOG00000055012 AllianceGenome:RGD:620764
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: FtsH1
Summary: Predicted to enable ATP-dependent peptidase activity. Predicted to be involved in several processes, including neuronal stem cell population maintenance; positive regulation of mitochondrial fusion; and protein catabolic process. Predicted to be located in mitochondrion and nuclear body. Predicted to be active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in optic atrophy 11. Orthologous to human YME1L1 (YME1 like 1 ATPase). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Thymus (RPKM 480.6), Spleen (RPKM 440.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17q12.3

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (90195485..90235675)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (85287607..85326068)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (89701899..89741919, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

PMC290270P1 (e-PCR)
- UniSTS:272416

D17Got106 (e-PCR)
- UniSTS:116080

REN92160 (e-PCR)
- UniSTS:416958

AF090430 (e-PCR)
- UniSTS:158924

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H2AZ histone chaperone activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H3-H4 histone complex chaperone activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent peptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP-dependent peptidase activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent peptidase activity	ISO Inferred from Sequence Orthology more info
enables ATP-dependent peptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables DNA clamp loader activity	IEA Inferred from Electronic Annotation more info
enables chromatin extrusion motor activity	IEA Inferred from Electronic Annotation more info
enables cohesin loader activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to starvation	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin looping	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial protein processing	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial protein processing	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial protein processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrion organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuronal stem cell population maintenance	IEA Inferred from Electronic Annotation more info
involved_in neuronal stem cell population maintenance	ISO Inferred from Sequence Orthology more info
involved_in neuronal stem cell population maintenance	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mitochondrial fusion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitochondrial fusion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial fusion	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein hexamerization	ISO Inferred from Sequence Orthology more info
involved_in protein maturation	IEA Inferred from Electronic Annotation more info
involved_in protein quality control for misfolded or incompletely synthesized proteins	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein quality control for misfolded or incompletely synthesized proteins	ISO Inferred from Sequence Orthology more info
involved_in protein quality control for misfolded or incompletely synthesized proteins	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of stem cell division	IEA Inferred from Electronic Annotation more info
involved_in regulation of stem cell division	ISO Inferred from Sequence Orthology more info
involved_in regulation of stem cell division	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ATP-dependent zinc metalloprotease YME1L1

Names: ATP-dependent metalloprotease FtsH1 homolog; ATP-dependent metalloprotease YME1L1; YME1-like protein 1; meg-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053682.2 → NP_446134.2 ATP-dependent zinc metalloprotease YME1L1

See identical proteins and their annotated locations for NP_446134.2

Status: PROVISIONAL

Source sequence(s)

BC081751

UniProtKB/Swiss-Prot

Q925S8

UniProtKB/TrEMBL

Q66HP7

Related

ENSRNOP00000080549.2, ENSRNOT00000108331.2

Conserved Domains (4) summary

TIGR01241
Location:275 → 708

FtsH_fam; ATP-dependent metalloprotease FtsH

pfam00004
Location:317 → 448

AAA; ATPase family associated with various cellular activities (AAA)

pfam01434
Location:528 → 706

Peptidase_M41; Peptidase family M41

cl21455
Location:273 → 337

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases