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St14 ST14 transmembrane serine protease matriptase [ Rattus norvegicus (Norway rat) ]

Gene ID: 114093, updated on 4-Jan-2025

Summary

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Official Symbol
St14provided by RGD
Official Full Name
ST14 transmembrane serine protease matriptaseprovided by RGD
Primary source
RGD:69288
See related
EnsemblRapid:ENSRNOG00000005903 AllianceGenome:RGD:69288
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
MT-SP1
Summary
Enables serine-type peptidase activity. Involved in protein catabolic process. Located in basolateral plasma membrane and extracellular space. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 11. Orthologous to human ST14 (ST14 transmembrane serine protease matriptase). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Kidney (RPKM 107.2), Lung (RPKM 55.9) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See St14 in Genome Data Viewer
Location:
8q13
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (37798994..37839881, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (29540805..29581704, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (32240113..32280813, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene small ubiquitin-related modifier 2-like Neighboring gene zinc finger and BTB domain containing 44 Neighboring gene amyloid beta precursor like protein 2 Neighboring gene uncharacterized LOC134480153

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Roles of CUB and LDL receptor class A domain repeats of a transmembrane serine protease matriptase in its zymogen activation. Inouye K, et al. J Biochem, 2013 Jan. PMID 23038671, Free PMC Article
  2. A role for membrane-type serine protease (MT-SP1) in intestinal epithelial turnover. Satomi S, et al. Biochem Biophys Res Commun, 2001 Oct 5. PMID 11573963
  3. Increased expression of matriptase is associated with histopathologic grades of cervical neoplasia. Lee JW, et al. Hum Pathol, 2005 Jun. PMID 16021568
  4. The occurrence of matriptase C-terminal fragments on the apical and basolateral sides of Madin-Darby canine kidney epithelial cells. Tsuzuki S, et al. Biosci Biotechnol Biochem, 2009 Nov. PMID 19897900
  5. The role of asparagine-linked glycosylation site on the catalytic domain of matriptase in its zymogen activation. Miyake Y, et al. Biochim Biophys Acta, 2010 Jan. PMID 19800422

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. investigation of protein structure of matriptase and the structural effects on kinetics of proteolysis and zymogen activation
    Title: Roles of CUB and LDL receptor class A domain repeats of a transmembrane serine protease matriptase in its zymogen activation.
  2. Identification of the matriptase second CUB domain as the secondary site for interaction with hepatocyte growth factor activator inhibitor type-1.
    Title: Identification of the matriptase second CUB domain as the secondary site for interaction with hepatocyte growth factor activator inhibitor type-1.
  3. It is concluded that N-glycosylation site at Asn772 of matriptase is required for the zymogen activation because it plays an important role in rendering this protease catalytically competent in the cellular environment.
    Title: The role of asparagine-linked glycosylation site on the catalytic domain of matriptase in its zymogen activation.
  4. Matriptase C-terminal fragments containing the catalytic serine protease domain were found to occur on the apical and basolateral sides of Madin-Darby canine kidney epithelial cells transfected with a cDNA encoding the protease.
    Title: The occurrence of matriptase C-terminal fragments on the apical and basolateral sides of Madin-Darby canine kidney epithelial cells.
  5. the activity of this protease was found to depend solely on the catalytic domain
    Title: The activity of a type II transmembrane serine protease, matriptase, is dependent solely on the catalytic domain.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables serine-type peptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables serine-type peptidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within epithelial cell morphogenesis involved in placental branching ISO
Inferred from Sequence Orthology
more info
  
involved_in keratinocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in keratinocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neural tube closure ISO
Inferred from Sequence Orthology
more info
  
involved_in protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
suppressor of tumorigenicity 14 protein
Names
matriptase
membrane-type serine protease
suppression of tumorigenicity 14 (colon carcinoma)
suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin)
NP_446087.1
XP_038936588.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053635.2 → NP_446087.1  suppressor of tumorigenicity 14 protein

    See identical proteins and their annotated locations for NP_446087.1

    Status: PROVISIONAL

    Source sequence(s)
    AB049189
    UniProtKB/TrEMBL
    A0A8I6ARC9, A0A9K3Y7V3, F1LRR7, Q9JJI7
    Related
    ENSRNOP00000009139.5, ENSRNOT00000009139.8
    Conserved Domains (4) summary
    cd00041
    Location:340 → 444
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00112
    Location:525 → 559
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:615 → 852
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam01390
    Location:88 → 178
    SEA; SEA domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    37798994..37839881 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039080660.2 → XP_038936588.1  suppressor of tumorigenicity 14 protein isoform X1

    UniProtKB/TrEMBL
    A0A8I6ARC9, A0A9K3Y7V3, F1LRR7, Q9JJI7
    Conserved Domains (4) summary
    cd00041
    Location:340 → 444
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00112
    Location:525 → 559
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:615 → 852
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam01390
    Location:88 → 178
    SEA; SEA domain
Nucleotide Protein Strain
Heading Accession and Version

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