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Pitx1 paired-like homeodomain 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 113983, updated on 9-Dec-2024

Summary

Official Symbol
Pitx1provided by RGD
Official Full Name
paired-like homeodomain 1provided by RGD
Primary source
RGD:69253
See related
EnsemblRapid:ENSRNOG00000011423 AllianceGenome:RGD:69253
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Bft
Summary
Enables DNA-binding transcription factor activity. Involved in regulation of DNA-templated transcription. Predicted to be located in cytoplasm. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in clubfoot. Orthologous to human PITX1 (paired like homeodomain 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Lung (RPKM 8.6) and Muscle (RPKM 3.9) See more
Orthologs
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Genomic context

See Pitx1 in Genome Data Viewer
Location:
17p14
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (8794051..8805477)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (8794134..8800292)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (8873184..8884428)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482673 Neighboring gene uncharacterized LOC120097949 Neighboring gene uncharacterized LOC103694034 Neighboring gene cation channel, sperm associated 3 Neighboring gene uncharacterized LOC134482674

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in anatomical structure morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within branchiomeric skeletal muscle development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cartilage development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic hindlimb morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in embryonic hindlimb morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within hindlimb morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within myoblast fate commitment ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within pituitary gland development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within skeletal system development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
pituitary homeobox 1
Names
homeobox protein PITX1
paired-like homeodomain transcription factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053624.2NP_446076.1  pituitary homeobox 1

    See identical proteins and their annotated locations for NP_446076.1

    Status: PROVISIONAL

    Source sequence(s)
    BC061966
    UniProtKB/Swiss-Prot
    Q99NA7
    UniProtKB/TrEMBL
    A6KAP5
    Related
    ENSRNOP00000015307.4, ENSRNOT00000015307.8
    Conserved Domains (2) summary
    pfam00046
    Location:93146
    Homeobox; Homeobox domain
    pfam03826
    Location:277294
    OAR; OAR domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    8794051..8805477
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063276016.1XP_063132086.1  pituitary homeobox 1 isoform X1

    UniProtKB/Swiss-Prot
    Q99NA7
    UniProtKB/TrEMBL
    A6KAP5
  2. XM_063276015.1XP_063132085.1  pituitary homeobox 1 isoform X1

    UniProtKB/Swiss-Prot
    Q99NA7
    UniProtKB/TrEMBL
    A6KAP5