Gucy2e guanylate cyclase 2E [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gucy2eprovided by RGD
Official Full Name: guanylate cyclase 2Eprovided by RGD
Primary source: RGD:69322
See related: EnsemblRapid:ENSRNOG00000015058 AllianceGenome:RGD:69322
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: GC-D; Gucy2d; ONE-GC; Gucy2ep
Summary: Enables guanylate cyclase activity and natriuretic peptide receptor activity. Involved in cGMP biosynthetic process and receptor guanylyl cyclase signaling pathway. Located in non-motile cilium and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 3.8), Muscle (RPKM 0.9) and 2 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1q32

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (162150967..162185666)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (152739775..152774474)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (163398891..163433594)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables guanylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanylate cyclase activity	IDA Inferred from Direct Assay more info	PubMed
enables natriuretic peptide receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables odorant binding	IEA Inferred from Electronic Annotation more info
enables odorant binding	ISO Inferred from Sequence Orthology more info
enables olfactory receptor activity	IEA Inferred from Electronic Annotation more info
enables olfactory receptor activity	ISO Inferred from Sequence Orthology more info
enables peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphorus-oxygen lyase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cGMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cGMP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in cGMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in detection of carbon dioxide	IEA Inferred from Electronic Annotation more info
involved_in detection of carbon dioxide	ISO Inferred from Sequence Orthology more info
involved_in detection of chemical stimulus involved in sensory perception of smell	IEA Inferred from Electronic Annotation more info
involved_in detection of chemical stimulus involved in sensory perception of smell	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in olfactory behavior	ISO Inferred from Sequence Orthology more info
involved_in olfactory learning	IEA Inferred from Electronic Annotation more info
involved_in olfactory learning	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cGMP-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cGMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in receptor guanylyl cyclase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor guanylyl cyclase signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in sensory perception of smell	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in ciliary membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in non-motile cilium	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: guanylate cyclase 2D

Names: guanylate cyclase 2E, pseudogene; guanylate cyclase, olfactory; olfactory guanylyl cyclase GC-D

NP_570093.2

EC 4.6.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130737.5 → NP_570093.2 guanylate cyclase 2D precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

F1M245, P51839

UniProtKB/TrEMBL

A0A8L2QA99, A6I6D7

Related

ENSRNOP00000020513.7, ENSRNOT00000020513.8

Conserved Domains (3) summary

smart00044
Location:861 → 1050

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

cd14043
Location:554 → 824

PK_GC-2D; Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-2D

cd06371
Location:71 → 445

PBP1_sensory_GC_DEF-like; ligand-binding domain of membrane guanylyl cyclases (GC-D, GC-E, and GC-F) that are specifically expressed in sensory tissues