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Ces1d carboxylesterase 1D [ Rattus norvegicus (Norway rat) ]

Gene ID: 113902, updated on 27-Nov-2024

Summary

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Official Symbol
Ces1dprovided by RGD
Official Full Name
carboxylesterase 1Dprovided by RGD
Primary source
RGD:70896
See related
EnsemblRapid:ENSRNOG00000015438 AllianceGenome:RGD:70896
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ces3
Summary
Enables retinyl-palmitate esterase activity. Predicted to be involved in several processes, including cellular response to cholesterol; cholesterol homeostasis; and regulation of steroid metabolic process. Predicted to act upstream of or within several processes, including cellular lipid catabolic process; circadian temperature homeostasis; and cold-induced thermogenesis. Located in intracellular membrane-bounded organelle. Biomarker of liver cancer. Human ortholog(s) of this gene implicated in colorectal cancer and gastrointestinal system cancer. Orthologous to human CES1 (carboxylesterase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 1509.9), Lung (RPKM 1198.8) and 6 other tissues See more
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Genomic context

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See Ces1d in Genome Data Viewer
Location:
19p11
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (30046494..30085039)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (13873490..13912035)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (15195514..15239827)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene carboxylesterase 1F Neighboring gene carboxylesterase 1E Neighboring gene carboxylesterase 1C Neighboring gene uncharacterized LOC134483613 Neighboring gene carboxylesterase 1A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Carboxylesterase 1 polymorphisms are associated with clinical outcomes in gastroenteric cancer patients treated with capecitabine. Liu D, et al. Cancer Chemother Pharmacol, 2021 May. PMID 33586000
  2. Hepatic carboxylesterase 3 (Ces3/Tgh) is downregulated in the early stages of liver cancer development in the rat. Quiroga AD, et al. Biochim Biophys Acta, 2016 Nov. PMID 27523631
  3. Mutation of residues 423 (Met/Ile), 444 (Thr/Met), and 506 (Asn/Ser) confer cholesteryl esterase activity on rat lung carboxylesterase. Ser-506 is required for activation by cAMP-dependent protein kinase. Wallace TJ, et al. J Biol Chem, 2001 Aug 31. PMID 11429416
  4. The carboxylesterase family exhibits C-terminal sequence diversity reflecting the presence or absence of endoplasmic-reticulum-retention sequences. Medda S, et al. Eur J Biochem, 1992 Jun 15. PMID 1606962
  5. Enhanced triacylglycerol catabolism by carboxylesterase 1 promotes aggressive colorectal carcinoma. Capece D, et al. J Clin Invest, 2021 Jun 1. PMID 33878036, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity IEA
Inferred from Electronic Annotation
more info
  
enables carboxylesterase activity ISO
Inferred from Sequence Orthology
more info
  
enables carboxylic ester hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carboxylic ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables carboxylic ester hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
enables fatty-acyl-ethyl-ester synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables retinyl-palmitate esterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sterol ester esterase activity ISO
Inferred from Sequence Orthology
more info
  
enables sterol ester esterase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables triacylglycerol lipase activity ISO
Inferred from Sequence Orthology
more info
  
enables triacylglycerol lipase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in acylglycerol catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in acylglycerol catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to cholesterol ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular response to cold ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to low-density lipoprotein particle stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in cholesterol biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cholesterol homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within circadian temperature homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cold-induced thermogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cytosolic lipolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lipid catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in medium-chain fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cholesterol storage ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cholesterol efflux ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of bile acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of bile acid secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in retinoid metabolic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in retinol metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in reverse cholesterol transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within short-chain fatty acid catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within very-low-density lipoprotein particle assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum lumen ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum lumen ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
  
located_in lipid droplet ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
carboxylesterase 1D
Names
ES-HVEL
FAEE synthase
carboxyesterase ES-10
carboxylesterase 3
fatty acid ethyl ester synthase
liver carboxylesterase 10
pI 6.1 esterase
NP_579829.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133295.3 → NP_579829.3  carboxylesterase 1D precursor

    See identical proteins and their annotated locations for NP_579829.3

    Status: VALIDATED

    Source sequence(s)
    BC061789, CF111142, CO574231
    UniProtKB/Swiss-Prot
    P16303, Q64574, Q6P785, Q91YG2, Q9QUX7, Q9R135
    UniProtKB/TrEMBL
    A0A0G2JY66, A6KD48
    Related
    ENSRNOP00000070536.2, ENSRNOT00000090865.3
    Conserved Domains (2) summary
    COG0657
    Location:121 → 239
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam00135
    Location:24 → 545
    COesterase; Carboxylesterase family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    30046494..30085039
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P16303.2 GenPept UniProtKB/Swiss-Prot:P16303

Gene LinkOut

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