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Etfa electron transferring flavoprotein, alpha polypeptide [ Mus musculus (house mouse) ]

Gene ID: 110842, updated on 27-Nov-2024

Summary

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Official Symbol
Etfaprovided by MGI
Official Full Name
electron transferring flavoprotein, alpha polypeptideprovided by MGI
Primary source
MGI:MGI:106092
See related
Ensembl:ENSMUSG00000032314 AllianceGenome:MGI:106092
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D9Ertd394e; 2010200I21Rik
Summary
Predicted to enable electron transfer activity; flavin adenine dinucleotide binding activity; and oxidoreductase activity. Predicted to be involved in amino acid catabolic process; fatty acid beta-oxidation using acyl-CoA dehydrogenase; and respiratory electron transport chain. Located in mitochondrion. Is expressed in several structures, including alimentary system; nervous system; respiratory system; sensory organ; and urinary system. Human ortholog(s) of this gene implicated in multiple acyl-CoA dehydrogenase deficiency. Orthologous to human ETFA (electron transfer flavoprotein subunit alpha). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in heart adult (RPKM 102.1), liver E18 (RPKM 85.4) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Etfa in Genome Data Viewer
Location:
9 B; 9 30.13 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (55361720..55419528, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (55454436..55512243, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene serpine1 mRNA binding protein 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9762 Neighboring gene transmembrane protein 266 Neighboring gene STARR-seq mESC enhancer starr_24189 Neighboring gene VISTA enhancer mm1754 Neighboring gene STARR-seq mESC enhancer starr_24190 Neighboring gene STARR-positive B cell enhancer ABC_E11406 Neighboring gene STARR-seq mESC enhancer starr_24191 Neighboring gene predicted gene 5917 Neighboring gene insulin related protein 2 (islet 2)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The mouse neuronal apoptosis inhibitory protein gene maps to a conserved syntenic region of mouse chromosome 13. DiDonato CJ, et al. Mamm Genome, 1997 Mar. PMID 9069126
  2. Hepatic neddylation targets and stabilizes electron transfer flavoproteins to facilitate fatty acid β-oxidation. Zhang X, et al. Proc Natl Acad Sci U S A, 2020 Feb 4. PMID 31941714, Free PMC Article
  3. cDNA cloning and mitochondrial import of the beta-subunit of the human electron-transfer flavoprotein. Finocchiaro G, et al. Eur J Biochem, 1993 May 1. PMID 8504797
  4. A DEAD-family protein gene, Ddx4, encoding a murine homolog of Drosophila vasa maps to the distal end of mouse chromosome 13. Abe K, et al. Mamm Genome, 1997 Aug. PMID 9250878
  5. Cloning, characterization, and copy number of the murine survival motor neuron gene: homolog of the spinal muscular atrophy-determining gene. DiDonato CJ, et al. Genome Res, 1997 Apr. PMID 9110173

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hepatic neddylation also enhances ETFA and ETFB expression in adult mice and prevents fasting-induced steatosis and mortality.
    Title: Hepatic neddylation targets and stabilizes electron transfer flavoproteins to facilitate fatty acid β-oxidation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables electron transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables electron transfer activity ISO
Inferred from Sequence Orthology
more info
  
enables electron transfer activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables electron transfer activity TAS
Traceable Author Statement
more info
 PubMed 
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables flavin adenine dinucleotide binding ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in amino acid catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in respiratory electron transport chain ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of electron transfer flavoprotein complex ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial electron transfer flavoprotein complex TAS
Traceable Author Statement
more info
 PubMed 
located_in mitochondrial matrix NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
electron transfer flavoprotein subunit alpha, mitochondrial
Names
Alpha-ETF

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145615.4 → NP_663590.3  electron transfer flavoprotein subunit alpha, mitochondrial

    See identical proteins and their annotated locations for NP_663590.3

    Status: VALIDATED

    Source sequence(s)
    AK028118, AV289509, BC096645, BY435583
    Consensus CDS
    CCDS23204.1
    UniProtKB/Swiss-Prot
    Q3THD7, Q3V000, Q4V9X5, Q8BMD3, Q8BMU7, Q99LC5
    Related
    ENSMUSP00000034866.9, ENSMUST00000034866.9
    Conserved Domains (3) summary
    PLN00022
    Location:3 → 333
    PLN00022; electron transfer flavoprotein subunit alpha; Provisional
    cd01715
    Location:21 → 181
    ETF_alpha; The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an ...
    pfam00766
    Location:211 → 293
    ETF_alpha; Electron transfer flavoprotein FAD-binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    55361720..55419528 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154563.1 → XP_036010456.1  electron transfer flavoprotein subunit alpha, mitochondrial isoform X1

    Conserved Domains (1) summary
    PLN00022
    Location:3 → 279
    PLN00022; electron transfer flavoprotein subunit alpha; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99LC5.2 GenPept UniProtKB/Swiss-Prot:Q99LC5

Gene LinkOut

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