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Tcrg T cell receptor gamma chain [ Mus musculus (house mouse) ]

Gene ID: 110067, updated on 11-Nov-2024

Summary

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Official Symbol
Tcrgprovided by MGI
Official Full Name
T cell receptor gamma chainprovided by MGI
Primary source
MGI:MGI:98623
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TCRGV1S1; TCRGV2S1; TCRGV3S1; TCRGV5S3
Summary
T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor gamma locus. The gamma locus includes V (variable), J (joining), and C (constant) segments. During T cell development, the gamma chain is synthesized by a recombination event at the DNA level joining a V segment with a J segment; the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random addition of nucleotides by terminal deoxynucleotidyltransferase. [provided by RefSeq, Jul 2008]
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Genomic context

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See Tcrg in Genome Data Viewer
Location:
13 A2; 13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (19362212..19540646)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (19178042..19356476)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53776 Neighboring gene STARR-seq mESC enhancer starr_33785 Neighboring gene amphiphysin Neighboring gene ribosomal protein 10 pseudogene Neighboring gene STARR-seq mESC enhancer starr_33786 Neighboring gene STARR-seq mESC enhancer starr_33787 Neighboring gene predicted gene, 31887 Neighboring gene STARR-seq mESC enhancer starr_33788 Neighboring gene STARR-seq mESC enhancer starr_33789 Neighboring gene T cell receptor gamma, variable 7 Neighboring gene T cell receptor gamma, variable 4 Neighboring gene T cell receptor gamma, variable 6 Neighboring gene T cell receptor gamma, variable 5 Neighboring gene T cell receptor gamma joining 1 Neighboring gene T cell receptor gamma, constant 1 Neighboring gene STARR-seq mESC enhancer starr_33790 Neighboring gene STARR-seq mESC enhancer starr_33791 Neighboring gene T cell receptor gamma, variable 3 Neighboring gene T cell receptor gamma joining 3 Neighboring gene T cell receptor gamma, constant 3 Neighboring gene T cell receptor gamma, constant 2 Neighboring gene T cell receptor gamma joining 2 Neighboring gene T cell receptor gamma variable 2 Neighboring gene STARD3 N-terminal like Neighboring gene STARR-seq mESC enhancer starr_33793 Neighboring gene T cell receptor gamma, variable 1 Neighboring gene T cell receptor gamma joining 4 Neighboring gene T cell receptor gamma, constant 4 Neighboring gene STARR-positive B cell enhancer mm9_chr13:19487566-19487867 Neighboring gene predicted gene, 40827 Neighboring gene cofilin 1, non-muscle pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Regulatory role of gammadelta T cells in the recruitment of CD4+ and CD8+ T cells to lung and subsequent pulmonary fibrosis. Simonian PL, et al. J Immunol, 2006 Oct 1. PMID 16982878
  2. The canonical T cell receptor of dendritic epidermal gamma delta T cells is highly conserved between rats and mice. Kühnlein P, et al. Eur J Immunol, 1996 Dec. PMID 8977309
  3. Efficient removal of loxP-flanked DNA sequences in a gene-targeted locus by transient expression of Cre recombinase in fertilized eggs. Sunaga S, et al. Mol Reprod Dev, 1997 Feb. PMID 9021742
  4. A novel element upstream of the Vgamma2 gene in the murine T cell receptor gamma locus cooperates with the 3' enhancer to act as a locus control region. Baker JE, et al. J Exp Med, 1999 Sep 6. PMID 10477551, Free PMC Article
  5. T cell receptor-gamma allele-specific selection of V gamma 1/V delta 4 cells in the intestinal epithelium. Grigoriadou K, et al. J Immunol, 2002 Oct 1. PMID 12244167

See all (205) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Host-derived mannose glycans trigger a pathogenic gammadelta T cell/IL-17a axis in autoimmunity.
    Title: Host-derived mannose glycans trigger a pathogenic γδ T cell/IL-17a axis in autoimmunity.
  2. Characteristics of gammadeltaTCR on myeloid cells from C57BL/6 mice with Plasmodium yoelii nigeriensis infection.
    Title: Characteristics of γδTCR on myeloid cells from C57BL/6 mice with Plasmodium yoelii nigeriensis infection.
  3. Increased TCRgammadelta signal strength profoundly prohibited the development of all IL-17A-secreting gammadelta T cells, regardless of Vgamma usage, but promoted the development of gammadelta progenitors along the IFNgamma pathway.
    Title: Strong TCRγδ Signaling Prohibits Thymic Development of IL-17A-Secreting γδ T Cells.
  4. Findings indicate a role for memory gammadelta T cells in orchestrating protective immune responses against intestinal pathogens.
    Title: IL-17A-producing resident memory γδ T cells orchestrate the innate immune response to secondary oral Listeria monocytogenes infection.
  5. Data show that inducible T cell co-stimulator (ICOS) deficient mice have a significant increase in the population of IL-17-producing Vgamma2+ gammadelta T cells in the thymus, spleen, lymph nodes and skin and exhibit exacerbated sensitization responses to 2,4-dinitrofluorobenzene.
    Title: Development of interleukin-17-producing Vγ2+ γδ T cells is reduced by ICOS signaling in the thymus.
  6. the majority of gammadelta T cells in the non-pregnant uterus, pregnant uterus, decidua and placenta of mice express the transcription factor RORgammat and produce interleukin-17 (IL-17).
    Title: The majority of murine γδ T cells at the maternal-fetal interface in pregnancy produce IL-17.
  7. This study revealed a generalized and transient increase of circulating gamma-delta T cell receptor, T cells in mice with small, aggressive intracranial GL261 gliomas and prior to the onset of neurologic symptoms.
    Title: Dynamics of Circulating γδ T Cell Activity in an Immunocompetent Mouse Model of High-Grade Glioma.
  8. Data indicate the function of promyelocytic leukaemia zinc finger PLZF in the development of innate-like interleukin-17, TcR gamma-delta (IL-17+Vgamma6+ gammadelta) T cells.
    Title: PLZF Controls the Development of Fetal-Derived IL-17+Vγ6+ γδ T Cells.
  9. IL-17-producing CD3(bright) gammadelta T cells responded promptly and strongly to pneumococcal infection and during skin inflammation.
    Title: CD3bright signals on γδ T cells identify IL-17A-producing Vγ6Vδ1+ T cells.
  10. Respiratory syncytial virus disease severity is in part mediated by a lack of inflammasome activation and IL-17A production in neonates.
    Title: Impaired gamma delta T cell-derived IL-17A and inflammasome activation during early respiratory syncytial virus infection in infants.
Submit: New GeneRIF Correction See all GeneRIFs (67)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (8)  1 citation

General gene information

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Markers

Other Names

  • TCR V gamma 1.3
  • TCR V gamma 2
  • TCR V gamma 3
  • TCR V gamma 4

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Names
T cell receptor gamma chain
TCR V gamma 1.3
TCR V gamma 2
TCR V gamma 3
TCR V gamma 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007033.1 

    Range
    501..178935
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    19362212..19540646
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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